Clinical usefulness of ^99mTc-HIgG scintigraphy for the abdominal inflammation

Clinical usefulness of 99m Tc-HIgG scintigraphy for the abdominal inflammation 1 first-author 1 Shanghai Hua-Dong Hospital, Shanghai 200040 Shanghai Hua-Dong Hospital, Shanghai 200040 This study was designed to evaluate the efficacy and safety of 99m Tc labeled human IgG as the tracer for detection of focal inflammatory lesion in abdomen. 61 inpatients with 20 documented cases of pelvicellulitis, 41 cases of inflammatory bowel diseases were studied. All their diagnosis were based upon clinical signs and various types of laboratory data and other imaging modalities. 370~740MBq/mg of 99m Tc-HIgG was injected intravenously. The whole body scan (Ant and Post views) were obtained 1, 2, 4, 6, 24 hours after injection, delayed imaging were repeated if necessary. Wherever abnormal areas, multiple spot views were added. 99m Tc-HIgG was avidly taken up by acute pelvis inflammation lesions and performed less well in 2 chronic cases, so the positive rate was 90%. 21 out of the 22 ulcerative colitis were positive, the positive rate was 93%. 17 out of the 19 Crohn's were positive, the positive rate was 89%. All the negative cases were not active ones. With respect to the activity of the disease, the positive rate of 99m Tc-HIgG scan in ulcerative colitis was 100% equal to that of endoscopy. In Crohn's disease the positive rate was 100%, while endoscopy and X-ray were 30% and 94% respectively. If both diseases were in their relief stage,the scans were normal. Thus 99m Tc-HIgG is proved to be effective in detecting the focal site of inflammation in the abdomen. Providing clinically useful assessment of disease activity and patient's response to therapy, 99m Tc-HIgG scintigraphy is safe, convenient with no side effects. Physiological accumulation in some organs such as the liver makes it difficult to localize. 99m Tc-HIgG SPECT imaging Crohn's disease Ulcerative colitis Pelvicellulitis References The P R C Health Ministry . Guidelines of diagnosis and treatment in nuclear medicine (in Chinese) . Beijing : Sci Technol Press , 1997 , 256 ~ 64 Guidelines of diagnosis and treatment in nuclear medicine (in Chinese) Jiang Mao-Song . Foreign Med Sci Sect Radiat Med Nucl Med (in Chinese) , 1997 , 21 : 272 ~ 76 Foreign Med Sci Sect Radiat Med Nucl Med (in Chinese) Oyen W J , Boerman Q C , Vander laken et al . Eur J Nucl Med , 1996 , 23 : 459 ~ 62 Eur J Nucl Med Buijs W C , Oyen W J , Dams E T et al . Nucl Med Commun , 1998 , 19 : 743 ~ 51 Nucl Med Commun Singh A K , Mishra P , Kashyap R , et al . Nucl Med Biol , 1994 , 21 : 277 ~ 78 Nucl Med Biol Scholmeroch J , Schmidt E , Schumichen C et al . Gastroenterology , 1988 , 95 : 1287 ~ 93 Gastroenterology R572, R817.4 2000-07-03 2000-11-01 2021-02-05 2000 Nuclear Science and Techniques 4 11