Effect of <sup>125</sup>I seeds and <sup>103</sup>Pd stents on proliferation of vascular smooth muscle cells

Jun ZHU; Quan-Yong LUO; Rui-Sen ZHU; Han-Kui LU

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Effect of ¹²⁵I seeds and ¹⁰³Pd stents on proliferation of vascular smooth muscle cells

更新时间：2021-02-05

- Effect of ¹²⁵I seeds and ¹⁰³Pd stents on proliferation of vascular smooth muscle cells
- Effect of ¹²⁵I seeds and ¹⁰³Pd stents on proliferation of vascular smooth muscle cells
- 核技术（英文版） 2002年13卷第4期
- 作者机构：
  
  1.Shanghai 6th People's Hospital, Shanghai 200233
- 作者简介：
- 基金信息：
- DOI：中图分类号： R817.1
- 纸质出版日期：2002-11-01，
  
  收稿日期：2002-01-14，
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Jun ZHU, Quan-Yong LUO, Rui-Sen ZHU, 等. Effect of ¹²⁵I seeds and ¹⁰³Pd stents on proliferation of vascular smooth muscle cells[J]. 核技术（英文版）, 2002, 13(4):218-223.

Jun ZHU, Quan-Yong LUO, Rui-Sen ZHU, et al. Effect of ¹²⁵I seeds and ¹⁰³Pd stents on proliferation of vascular smooth muscle cells[J]. Nuclear Science and Techniques, 2002, 13(4):218-223.
Jun ZHU, Quan-Yong LUO, Rui-Sen ZHU, 等. Effect of ¹²⁵I seeds and ¹⁰³Pd stents on proliferation of vascular smooth muscle cells[J]. 核技术（英文版）, 2002, 13(4):218-223. DOI：

Jun ZHU, Quan-Yong LUO, Rui-Sen ZHU, et al. Effect of ¹²⁵I seeds and ¹⁰³Pd stents on proliferation of vascular smooth muscle cells[J]. Nuclear Science and Techniques, 2002, 13(4):218-223. DOI：

Effect of 125 I seeds and 103 Pd stents on proliferation of vascular smooth muscle cells 1 first-author 1 1 1 Shanghai 6th People's Hospital, Shanghai 200233 Shanghai 6th People's Hospital, Shanghai 200233 This study aims at the theoretical and practical evidence for prevention of restenosis in vitro. Vascular smooth muscle cell (VSMC) model was established using adherent cell culture methods. The proliferation of VSMC was investigated by the cell counting method and 3 H-TDR implementation test. The results are as follows. (1) For 125 I-seeds, the inhibition rate was 29.3% at 74Bq ( p < 0.05), 35.2% at 148Bq ( p < 0.05) and 42.4% at 370Bq ( p < 0.05), For 103 Pd-implanted stents, the inhibition rate was 14.7% at 4.44 MBq ( p < 0.05), 24.0% at 5.92 MBq ( p < 0.05) and 38.0% at 7.4 MBq ( p < 0.05), There was no significant difference between the blank tests and non-radioactive tests. (2) 48 hours exposure from 125 I-seeds at 148 Bq or 103 Pd-implanted stents at 7.4 MBq did not result in VSMC's morphological alteration, but that from 125 I-seeds at 370Bq caused morphological changes, Both 125 I-seeds and 103 Pd-implanted stents inhibit the VSMC DNA synthesis in vitro. The inhibition effects are significantly related to their exposure duration and doses. 125 I-seeds 103 Pd-implanted stents Vascular smooth muscle cell References Faxon D P , Verin V , Urban P. Ann New York Acad Sci , 1995 , 748 : 419 - 428 Ann New York Acad Sci Liu M N , Roubin G S , King S B III . Circulation , 1989 , 79 : 1374 - 1385 Circulation Macleod , Strauss B H , De Jong M et al . J Am Coll Cardiol , 1994 , 23 : 59 - 65 J Am Coll Cardiol Fishman D L , Leon M B , Baim DS et al . New Engl J M , 1994 , 331 : 496 - 501 New Engl J M Carter A J , Laird J R , Farb A et al . J Am Coll Cardiol , 1994 , 24 : 1398 - 1405 J Am Coll Cardiol Hanke H , Strohschneider T , Oberhoff M et al . Circ Res , 1990 , 67 : 6512 - 6519 Circ Res R817.1 2002-01-14 2002-11-01 2021-02-05 2002 Nuclear Science and Techniques 4 13

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Effect of 125I seeds and 103Pd stents on proliferation of vascular smooth muscle cells

Effect of ¹²⁵I seeds and ¹⁰³Pd stents on proliferation of vascular smooth muscle cells