Advantages and disadvantages of nuclear reactions used in reactors or cyclotrons, in addition to a theoretical study based on photo-disintegration on natural indium for ¹¹¹Ag production

Advantages and disadvantages of nuclear reactions used in reactors or cyclotrons, in addition to a theoretical study based on photo-disintegration on natural indium for 111 Ag production 1 corresp first-author Khaled M. El-Azony mmenaa_2004@yahoo.com Khaled M. El-Azony mmenaa_2004@yahoo.com mmenaa_2004@yahoo.com https://orcid.org/0000-0002-5583-3822 2 3 Radioactive Isotopes and Generators Department, Hot Labs. Center, Egyptian Atomic Energy Authority, P. O. Box 13759, Cairo, Egypt Radioactive Isotopes and Generators Department, Hot Labs. Center, Egyptian Atomic Energy Authority, P. O. Box 13759, Cairo, Egypt Reactors Department, Egyptian Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt Reactors Department, Egyptian Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt Physics Department, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia Physics Department, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia Production routes were recorded on available reactions for 111 Ag production from nuclear reactors or cyclotrons using a natural palladium target based on 110 Pd(n, γ) and 110 pd(d, n) reactions, respectively. nat Cd(γ, x) based on 110 Cd(γ, p) has also been studied as a prospective reaction for the production of 111 Ag. Unfortunately, these nuclear reactions are difficult to utlize because, in some cases, they reduce the specific activity of 111 Ag. This is a consequence of the stable silver isotopes produced in high concentrations. These isotopes include 107, 109 Ag and, in other cases, the high impurity of silver radioisotopes, such as 110m, 106m, 105 Ag, that are produced during parallel nuclear reactions. Due to a scarcity of data regarding the (γ, α) reaction, the gamma reaction on natural indium for 111 Ag production based on the 115 In(γ, α) reaction was calculated. The nat In(γ, α) reaction satisfies the criteria as a possible reaction to produce 111 Ag with a sufficient yield and purity as consequence of the high 115 In (95.7 %) abundance as an enriched form and a relatively soft background caused by the parallel nuclear reactions. Silver-111 Nuclear data Natural cadmium Natural palladium Natural indium. Introduction 1 Silver has long been recognized as an antimicrobial and therapeutic metal, frequently used for the treatment of a number of superficial wounds, bruises, and mild burns [ 1 1 , 2 2 ]. The incorporation of silver into several pharmaceuticals is a common commercial in medical applications [ 3 3 - 7 7 3-7 ]. Several radionuclides, including 165 Dy, 169 Er, 198 Au, 166 Ho, 177 Lu, 32 P, 186 Re, 153 Sm, 89 Sr, 182 Ta 170 Tm, and 90 Y, have been used as therapeutic agents as a conseqence of the linear energy transfer (LET) property resuling from beta particle decay [ 8 8 - 10 10 8-10 ]. Recently, radionuclide theranostic concepts in nuclear medicine have demonstrated that gamma-ray decay or positron emission, as well as beta-particle emission, can be used for both diagnostic and therapeutic purposes [ 11 11 - 13 13 11-13 ]. Referring to 111 Ag as a radionuclide ( t 1/2 = 7.45 d), it has β - - particle emission ( E max =1.04 MeV) [ 14 14 ] and γ-rays at energies of 245 keV (1.3%) and 342 keV (6.7%) suitable for detection [ 15 15 ]; consequently, it has theranostic properties [ 16 16 ] owing to its characteristic decay state, as shown in Table 1 Table 1 . The length of beta-emitting in tissue ranged from one to ten millimeters based on the quantity of energy emitted; consequently, it is ideal for medium to large tumors [ 17 17 ]. In addition, the decay of 111 Ag produces low gamma rays, allowing simultaneous SPECT imaging. The combination of diagnostic and therapeutic uses in the same isotope enables parallel therapy as well as in vivo dose monitoring [ 18 18 ]. Furthermore, the relatively long half-life of 111 Ag is compatable with the biological half-lives of antibodies; consequently, this isotope is attractive for application in radio-immunotherapy [ 19 19 , 20 20 ]. 111 Ag has been produced using a variety of nuclear reactions based on nuclear reactors [ 21 21 , 22 22 ] and cyclotrons [ 23 23 - 25 25 23-25 ]. Thermal neutron irradiation of natural palladium targets produces an intermediate of 111 Pd radionuclide via a 110 Pd(n, γ) 111 Pd reaction, and then the short-lived 111 Pd ( t 1/2 =23.4 min) decays to 111 Ag [ 21 21 , 22 22 ]. Unfortunately, the cross-section of the 110 Pd(n, γ) reaction is small (0.34 b) [ 26 26 , 27 27 ], and the presence of six stable palladium isotopes permits the numerous simultaneous nuclear reactions that reduce the purity and activity of 111 Ag. Deuteron induced reactions have been studied to produce 111 Ag by 110 Pd(d, n) and nat Pd(d, x) [ 23 23 - 25 25 23-25 ] and resulting in an inescapable co-production of 110m Ag ( t 1/2 =249.83 d) in both reactions in addition to the presence of many silver radioisotopes produced due to a variety of nuclear reactions occurring on natural palladium. The yields of photonucleon reactions with different multiplicities that occur on a natural mixture of cadmium isotopes were measured in order to produce 111 Ag via a nat Cd (γ, p) reaction based on the 112 Cd (γ, p) reaction using Bremsstrahlung as a gamma-ray source with an endpoint energy of 55 MeV [ 28 28 ]. 1 1 Radionuclide 1 1 t 1/2 3 1 Therapeutic application 4 1 Diagnostic application 1 1   1 1   1 1 Mode of decay 2 1 Corpuscular radiation 2 1 Postron emission 2 1 Main γ-rays 1 1   1 1   1 1   1 1 E β -(keV) 1 1 I β - (%) 1 1 E β + (keV) 1 1 I β + (%) 1 1 E γ (keV) 1 1 I γ (%) 1 1 103 Ag 1 1 65.7 m 1 1 ε+β + (100%) 1 1   1 1   1 1 1134.09 1 1 1.6 1 1 118.72 1 1 31.2 1 1   1 1   1 1   1 1   1 1   1 1 1399.14 1 1 14.8 1 1 148.19 1 1 28.3 1 1   1 1   1 1   1 1   1 1   1 1 1422.10 1 1 2.1 1 1 243.9 1 1 9.0 1 1   1 1   1 1   1 1   1 1   1 1 1666.00 1 1 8.3 1 1 266.86 1 1 13.3 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 531.86 1 1 8.75 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 742.11 1 1 2.54 1 1 104 Ag 1 1 69.2 m 1 1 ε+β + (100%) 1 1   1 1   1 1 991.69 1 1 5.1 1 1 444.5 1 1 1.7 1 1   1 1   1 1   1 1   1 1   1 1 1075.44 1 1 2.9 1 1 555.796 1 1 92.6 1 1   1 1   1 1   1 1   1 1   1 1 1174.62 1 1 4.1 1 1 740.67 1 1 7.2 1 1   1 1   1 1   1 1   1 1   1 1 1933.41 1 1 1.9 1 1 758.76 1 1 6.4 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 767.72 1 1 65.7 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 785.86 1 1 9.5 1 1 105 Ag 1 1 41.29 d 1 1 ε+β + (100%) 1 1   1 1   1 1 - 1 1   1 1 63.98 1 1 10.5 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 280.41 1 1 30.2 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 319.14 1 1 4.35 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 344.52 1 1 41 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 443.37 1 1 10.5 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 644.55 1 1 11.1 1 1 106m Ag 1 1 8.28 d 1 1 ε+β + (100%) 1 1   1 1   1 1   1 1   1 1 406.18 1 1 13.4 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 429.65 1 1 13.2 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 450.98 1 1 28.2 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 616.17 1 1 21.6 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 717.34 1 1 28.9 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 748.36 1 1 20.6 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 804.28 1 1 12.4 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 824.69 1 1 15.3 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 1045.83 1 1 29.6 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 1527.65 1 1 16.3 1 1 110m Ag 1 1 249.8 d 1 1 IT (1.33), β - (98.67) 1 1 83.0 1 1 66.8 1 1   1 1   1 1 657.76 1 1 94 1 1   1 1   1 1   1 1 133 1 1 0.41 1 1   1 1   1 1 677.62 1 1 10.28 1 1   1 1   1 1   1 1 529.84 1 1 30.45 1 1   1 1   1 1 706.68 1 1 16.33 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 763.94 1 1 22.14 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 884.68 1 1 72.20 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 937.49 1 1 34.13 1 1   1 1   1 1   1 1   1 1   1 1   1 1   1 1 1384.29 1 1 24.12 1 1 111 Ag 1 1 7.45 d 1 1 β - (100%) 1 1 694.67 1 1 7.1 1 1   1 1   1 1 245.395 1 1 1.33 1 1   1 1   1 1   1 1 1036.8 1 1 92.5 1 1   1 1   1 1 342.13 1 1 7.00 As a result, photon-induced reactions were emphasized as electromagnetic radiation with a moderate energy of roughly (20-25) MeV that perturbs the nucleons in the target nucleus, causing the product particles to be released [ 29 29 , 30 30 ], and evidence for the regular threshold dependence of photon-induced reactions were observed. For the emission of alpha particles, reactions occur at the sum of the reaction threshold ( E th ) and the Coulomb barrier ( B c ). For many decades, researchers have investigated the (γ, α) reaction for light targets. However, literature data for medium-weight and heavy targets are limited. Cross-sections of electro- and photo-nuclear reactions were studied on 58 Ni and 60 Ni targets [ 31 31 , 32 32 ]. The product yields of (γ, α) reactions with antimony targets have been reported [ 33 33 ]. The yield of 117 In in the 121 Sb(γ, α) reaction has also been reported to be close to 0.8% of the (γ, n) yield, which is much greater than that obtained by Volkov et al., 1980 [ 31 31 ]. The yield of the (γ, α) reaction was found less than that of the (γ, p) reaction by a factor of 20, i.e. roughly 10 -4 of the rate of the (γ, n) reaction [ 28 28 ]. Due to contradictory results in the literature, as well as a general lack of reliable evidence, it can be concluded that there is a need to investigate the relative yields of bremsstrahlung-induced reactions, particularly in the case of (γ, α) reactions to heavy targets such as natural indium for the production of 111 Ag. This work evaluates 111 Ag production methods based on accessible nuclear reactions, taking into consideration the target selection that provides the lowest cost, largest yield, and best purity, by evaluating nuclear data for all feasible nuclear reactions. Production route 1 The criteria for producing 111 Ag as a theranostic radioisotope are based on reaction selection, which achieves high radionuclidic purity with high specific activity via projectile type, energy, and isotopic abundance in the target, as well as high chemical purity via chemical separation methods, as shown in Table 2 Table 2 . Although several nuclear reactions, including nuclear reactors via nat Pd (n, γ) reactions [ 21 21 , 22 22 ] and cyclotrons via 232 Th(p, f) and nat Pd (d, n) reactions [ 16 16 , 34 34 ], are used for 111 Ag production, an additional factor associated with the type of nuclear reaction is the chemical separation route. This is governed by yield, purity, and separation duration. The separation yield of 111 Ag based on the (n, γ) reaction was performed with a yield of 80–82 % and a suitable chemical purity for use in nuclear medicine, where the palladium concentration was measured to be 1–2 µg [ 21 21 , 22 22 ]. Unfortunately, 111 Ag was produced with low specific activity due to the high concentration of stable isotope 109 Ag product (90GBq/mg at 24 h irradiation time and 5 × 10 13 n cm -2 S -1 neutron flux) [ 21 21 ]. According to the literature, two nuclear reactions, 232 Th (p, f) and 110 Pd(d, n), were used in the cyclotron to produce 111 Ag. Although the activity of 111 Ag produced in the (p, f) reaction is very significant, the fission reactions produce several radionuclides, resulting in a high proportion of radioactive impurities and the difficulty of separating 111 Ag with high purity, as well as a separation method that requires significant time. Furthermore, a 110m Ag long-lived radioisotope ( t 1/2 = 249.83 d) with a relatively high ratio of 0.1% (0.518 GBq) that could not be separated. Deuterium reactions have been studied on the 110 Pd(d, n) 111 Ag [ 36 36 ], but these routes are limited by the small 110 Pd deuterium capture cross-section and the unavoidable co-production of the 110m Ag. In the medical context, typical 111 Ag radiotherapeutic doses range from 3700 to 7400 MBq (100 to 200 mCi) per patient [ 24 24 , 37 37 ]. The properties of the nuclear reactions are discussed individually below. 1 1 Nuclear reaction 1 1 Conditions 1 1 Mass(mg) 1 1 Separation route 1 1 Seprartion time 1 1 Yield(%) 1 1 111 Ag(GBq) 1 1 Chemicalpurity 1 1 Radionuclidic purity (%) 1 1 Ref. 1 1 nat Pd(n,γ) 111 Ag 1 1 26 h at a neutron fluxof 3 × 10 13 n cm -2 s -1 1 1 100 1 1 75 mL of toluene/triphenylphosphine (TPP, 0.0014M) and 5 mL of acetate buffer pH 6 are used in a liquid-liquid extraction technique. 1 1 ~ 120-180 min 1 1 82 1 1 0.067 1 1 2.2 µg Pd 1 1   1 1 [ 21 21 ] 1 1 nat Pd(n,γ) 111 Ag 1 1 72 h at a neutron flux of 1014 n cm -2 s -1 1 1 100 1 1 The ion exchange column technique has been used, which involved passing 30 mL of the dissolved target in 0.01M HCl on the acidic alumina column at a flow rate of 1 mL/min, then removing Pd with 0.1 M HCl and eluting 111 Ag with 4M HCl. 1 1 ~ 120 min 1 1 80 1 1   1 1 > 1 µg Pd 1 1   1 1 [ 22 22 ] 1 1 232 Th(p,f) 111 Ag 1 1 22.5 h with 200 µA of 90 MeV protons 1 1 10000 1 1 Column chromatographic method that uses CL resin to separate no-carrier-added 111 Ag from proton irradiatedthorium target and associated fission products as an ancillary process to 225 Ac separation design. 1 1 180-240 min 1 1 94 1 1 518 1 1   1 1 > .990.1% 110m Ag 1 1 [ 34 34 ] 1 1 nat Pd(d,x) 111 Ag 1 1 4h with 5µA of 9 MeV protons 1 1   1 1 The irradiated nat Pd target was dissolved in a mixture solution of the HNO 3 and HCl concentrated, then the evaporation process to almost dryness, the residue was dissolved in diluted HNO 3 solution and fed into an anion exchange column such as AG1-X8. The elution of 111 Ag has been performed by 2 M HNO 3 solution. 1 1   1 1 >92 1 1   1 1 <25 ppb of Pd 1 1   1 1 [ 16 16 , 35 35 ] nat Pd(n,x) 111 Ag reaction 2 Natural palladium was irradiated in a nuclear reactor [ 21 21 , 22 22 ]. The 111 Ag activity concentration in the irradiated target was determined using Eq. (1): <math display="block" id="M1"><mrow><mi>A</mi><mo>=</mo><mfrac><mrow><msub><mi>N</mi><mrow><mtext>net</mtext></mrow></msub></mrow><mrow><msub><mi>I</mi><mi>γ</mi></msub><mo> </mo><mi>t</mi></mrow></mfrac></mrow></math> where A is the activity concentration of 111 Ag by Becquerel (disintegration per second), N net is the net area under the peak of 695 keV, while ε the absolute efficiency of the detector at the given gamma energy, I γ is the branching ratio (7.1%) of the given gamma energy, and t is the measurement time. The quantity of produced stable 109 Ag isotope (μg) may be calculated by using the Avogadro number to estimate the number of radionuclides ( N ) in 109 Pd by knowing its activity ( A ) measured by Eq. (1) at a gamma energy peak of 88 keV, which has a branching ratio ( I γ ) of 3.6%. Because both activity A and the half-life of 109 Pd (13.7 h) are known, equation (2) can be used to determine the number of radionuclides for 109 Pd. <math display="block" id="M2"><mrow><mi>N</mi><mo>=</mo><mfrac><mi>A</mi><mi>λ</mi></mfrac></mrow></math> where λ is the decay constant. The mass of 109Ag (g) was calculated using Eq.(3). <math display="block" id="M3"><mrow><mi>m</mi><mo> </mo><mrow><mo>(</mo><mtext>g</mtext><mo>)</mo></mrow><mo>=</mo><mfrac><mrow><mn>109</mn></mrow><mrow><msub><mi>N</mi><mtext>A</mtext></msub></mrow></mfrac><mo>×</mo><mi>N</mi><mo>,</mo></mrow></math> where N A is the Avogadro's number. nat Pd(d,x) 111 Ag reaction 2 Excitation functions were accomplished by stacked-foil activation on natural palladium by deutron-induced reactions in medium-energy cyclotron [ 23 23 - 25 25 23-25 ] using a small beam current, after which the irradiated targets were measured by high-resolution gamma-ray spectroscopy. The cross-sections of 103, 104, 105, 106m, 110m, 111 Ag were calculated using the standard activation Eq. (4). <math display="block" id="M4"><mrow><mi>σ</mi><mo>=</mo><mfrac><mrow><msub><mi>T</mi><mi>γ</mi></msub></mrow><mrow><msub><mi>ε</mi><mi>d</mi></msub><msub><mi>ε</mi><mi>γ</mi></msub><msub><mi>ε</mi><mi>t</mi></msub><msub><mi>N</mi><mi>t</mi></msub><msub><mi>N</mi><mi>b</mi></msub><mrow><mo>(</mo><mrow><mn>1</mn><mo>−</mo><msup><mi>e</mi><mrow><mo>−</mo><msub><mi>t</mi><mi>b</mi></msub></mrow></msup></mrow><mo>)</mo></mrow><msup><mi>e</mi><mrow><mo>−</mo><msub><mi>t</mi><mi>c</mi></msub></mrow></msup><mrow><mo>(</mo><mrow><mn>1</mn><mo>−</mo><msup><mi>e</mi><mrow><mo>−</mo><msub><mi>t</mi><mi>m</mi></msub></mrow></msup></mrow><mo>)</mo></mrow></mrow></mfrac></mrow></math> where N t is the surface density of the target atoms, N b is the number of bombarding particles per unit time, T γ is the photo-peak number count, ε d is the efficiency of the detector, ε γ is the gamma-ray intensity, ε t is the dead time of measurement, which is the ratio of live time to real time, λ is the decay constant, t b is the time of irradiation, t c is the time of cooling, and t m is the time of acquisition. The data obtained from cross-section reactions play a very important role in the production of radionuclides by cyclotrons, as described earlier [ 38 38 , 39 39 ]. In order to be able to determine the yield with a good accuracy, one needs to know the full excitation functions. Therefore, the estimated yield of a product within a certain energy range, that is, the target thickness, may be determined using Eq. (5): <math display="block" id="M5"><mrow><mi>Y</mi><mo>=</mo><mfrac><mrow><msub><mi>N</mi><mtext>A</mtext></msub><mi>H</mi></mrow><mi>M</mi></mfrac><mi>I</mi><mo stretchy="false">(</mo><mn>1</mn><mo>−</mo><msup><mi>e</mi><mrow><mo>−</mo><mi>λ</mi><mi>t</mi></mrow></msup><mo stretchy="false">)</mo><msup><mrow><mstyle displaystyle="true"><mrow><msubsup><mo>∫</mo><mrow><mi>E</mi><mn>1</mn></mrow><mrow><mi>E</mi><mn>2</mn></mrow></msubsup><mrow><mrow><mo>[</mo><mrow><mfrac><mrow><mtext>d</mtext><mi>E</mi></mrow><mrow><mtext>d</mtext><mo stretchy="false">(</mo><mi>ρ</mi><mi>x</mi><mo stretchy="false">)</mo></mrow></mfrac></mrow><mo>]</mo></mrow></mrow></mrow></mstyle></mrow><mrow><mo>'</mo><mo>−</mo><mn>1</mn></mrow></msup><mi>σ</mi><mo stretchy="false">(</mo><mi>E</mi><mo stretchy="false">)</mo><mtext>d</mtext><mi>E</mi></mrow></math> where Y is the yield of the activity concentration of the product by Becquerel, H is the enrichment (or isotopic abundance) of the target nuclide, M is the mass number of the target element, σ ( E ) is the cross section within a certain energy range, ρ is the density of the target material, and x is the projectile distance travelled through the target material. Photonuclear reactions 2 Experimental photonuclear reaction data are typically collected by directly recording the number of particles released or by measuring the residual nuclear activity. In the case of energies that exceed the multi-particle emission threshold, more than one combination of emitted light particles may associate the same number of neutrons produced or may contribute to the same residual nucleus. The experimental data collection recorded for the (γ, n) cross-section may contain charged particles released at the same time as a single neutron emission, that is, (γ, 1n)+(γ, 1np)+(γ, n2p)….etc., which depend on the incident photon energy. Continuous bremsstrahlung spectra are generated by impacting the target with an electron beam from the accelerator (initially betatrons and synchrotrons, and now, linear accelerators). The photon energy spectrum is continuous, and the yield of the reaction Y(E o ) can be measured as in equation (6): [ 28 28 ] <math display="block" id="M6"><mrow><mi>Y</mi><mrow><mo>(</mo><mrow><msub><mi>E</mi><mtext>o</mtext></msub></mrow><mo>)</mo></mrow><mo>=</mo><msub><mi>N</mi><mi>R</mi></msub><mstyle displaystyle="true"><mrow><msubsup><mo>∫</mo><mrow><msub><mi>E</mi><mrow><mtext>th</mtext></mrow></msub></mrow><mrow><msub><mi>E</mi><mn>0</mn></msub></mrow></msubsup><mrow><mfrac><mrow><mi>σ</mi><mrow><mo>(</mo><mrow><msub><mi>E</mi><mi>γ</mi></msub></mrow><mo>)</mo></mrow></mrow><mrow><msub><mi>E</mi><mi>γ</mi></msub></mrow></mfrac><mi>W</mi><mrow><mo>(</mo><mrow><msub><mi>E</mi><mn>0</mn></msub><msub><mi>E</mi><mi>γ</mi></msub></mrow><mo>)</mo></mrow><mtext>d</mtext><msub><mi>E</mi><mi>γ</mi></msub></mrow></mrow></mstyle><mo>,</mo></mrow></math> where E γ is the photon energy, σ ( E γ ) is the reaction cross-section, W is the bremsstrahlung energy-dependent photon flux, E 0 is the endpoint energy of the bremsstrahlung spectrum relative to the electron beam energy, is the threshold energy, and N R is the standardized coefficient. Adjusting the E 0 by simple changes allows the measurement of the yield curve, and then the use of the "unfolding" technique achieves a cross section for the photonuclear reaction. The benefit of bremsstrahlung measurements is the high photon beam intensity, which introduces the possibility of achieving sufficient statistics even with very limited cross-section reactions. However, this technique has many challenges [ 28 28 ]. It is necessary to know more regarding the bremsstrahlung spectrum for all electron energies. Then, γ- analysis of the residual nucleus is performed after irradiation of the target by bremsstrahlung  at varying endpoint energies [ 28 28 - 30 30 28-30 ]. From the γ-lines, the photo nuclear reaction cross-sections were calculated. The photon charged particle reaction cross sections, σ (γ, p) and σ (γ , α), respectively, are insufficient and limited in the literature, and do not contain photon fission reactions. natCd(γ,x)111Ag reaction 3 The RM-55 microtron (55 MeV) was used for the irradiation experiments, as illustrated in Fig. 1 Fig. 1 . A tungsten braking converter (2.2 mm tungsten thickness) was used to generate bremsstrahlung radiation. The CdO target powder occupied an area of 6.3 cm 2 [ 28 28 ]. The cadmium target was placed directly behind the braking target. The gamma radiation dose was monitored with the aid of a Faraday cylinder. The target is irradiated for a known duration and then transported for gamma-ray spectrum measurement by the Hp-Ge detector. The reaction yield ( Y ) was calculated using the following Eq. (7): <math display="block" id="M7"><mrow><mi>Y</mi><mo>=</mo><mfrac><mrow><msub><mi>S</mi><mstyle mathvariant="bold" mathsize="normal"><mi>γ</mi></mstyle></msub></mrow><mrow><msub><mi>ε</mi><mstyle mathvariant="bold" mathsize="normal"><mi>γ</mi></mstyle></msub><msub><mi>I</mi><mstyle mathvariant="bold" mathsize="normal"><mi>γ</mi></mstyle></msub><mrow><mo>(</mo><mrow><mn>1</mn><mo>−</mo><msup><mi>e</mi><mrow><mo>−</mo><msub><mi>t</mi><mn>1</mn></msub></mrow></msup></mrow><mo>)</mo></mrow><msup><mi>e</mi><mrow><mo>−</mo><msub><mi>t</mi><mn>2</mn></msub></mrow></msup><mrow><mo>(</mo><mrow><mn>1</mn><mo>−</mo><msup><mi>e</mi><mrow><mo>−</mo><msub><mi>t</mi><mn>3</mn></msub></mrow></msup></mrow><mo>)</mo></mrow></mrow></mfrac></mrow></math> where S γ is the count rate of gamma rays under the peak, ε γ is the efficiency of the gamma-ray detector at the specific energy, λ is the decay constant of a radionuclide produced, I γ is the branching ratio of gamma rays for the radionuclide produced by that specific energy, t 1 , t 2 , t 3 are the irradiation, cooling, and the measurement times, respectivley. nat In(γ,x) 111 Ag reaction 3 The following equation governs the activity A ( t ) of a produced radioisotope when a target is irradiated in a nuclear radiation flux: [ 40 40 ]: <math display="block" id="M8"><mrow><mi>A</mi><mrow><mo>(</mo><mi>t</mi><mo>)</mo></mrow><mo>=</mo><mi>R</mi><mrow><mo>(</mo><mrow><mn>1</mn><mo>−</mo><msup><mi>e</mi><mrow><mo>−</mo><mi>λ</mi><mi>t</mi></mrow></msup></mrow><mo>)</mo></mrow><mo>,</mo></mrow></math> where R is the rate of nuclear interaction and can be expressed by Eq. (9), where λ is the decay constant of the radionuclide formed. <math display="block" id="M9"><mrow><mi>R</mi><mo>=</mo><mi>N</mi><msub><mrow><mtext> σ</mtext></mrow><mrow><mtext>eff</mtext></mrow></msub><mo> </mo><mi>ϕ</mi><mo>,</mo></mrow></math> N is the number of atoms in the target for a given nuclide, as calculated by equation (10), σ eff denotes the effective cross section of the reaction, and φ represents the radiation flux. <math display="block" id="M10"><mrow><mi>N</mi><mo>=</mo><mfrac><mrow><mi>a</mi><mo> </mo><mi>m</mi><mo> </mo><msub><mi>N</mi><mtext>A</mtext></msub></mrow><mi>M</mi></mfrac><mo> </mo></mrow></math> where <math id="M11"><mrow><mi>a</mi><mo> </mo></mrow></math> and <math id="M12"><mi>M</mi></math> are the abundance and atomic mass of the nuclide, <math id="M13"><mi>m</mi></math> is the mass of the element in the target. The analysis assumes that a natural indium target is exposed to a bremsstrahlung radiation beam produced by an electron accelerator at the energy distributions provided in Ref. [ 41 41 ], particularly at the endpoint energy of 24 MeV for the production of 111 Ag through the (γ, α) reaction. Indium has two naturally occurring stable isotopes, 113 In and 115 In, with natural abundances of 0.0429 and 0.9571, respectively. As a consequence of the (γ, α) reaction, the undesirable stable 109 Ag is produced alongside the radioisotope 111 Ag. The 109 Ag production is based on the abundance of 113 In on the natural indium target. Figure 2 Figure 2 illustrates the (γ, α) reaction cross-sections of the two isotopes, and the threshold energy for both nuclides is approximately 10 MeV. The effective cross section can be calculated as follows: <math display="block" id="M14"><mrow><mo> </mo><msub><mi>σ</mi><mrow><mtext>eff</mtext></mrow></msub><mo>=</mo><mfrac><mrow><msubsup><mstyle mathsize="140%" displaystyle="true"><mo>∫</mo></mstyle><mrow><mn>10</mn><mo> </mo><mtext>MeV</mtext></mrow><mrow><mn>24</mn><mo> </mo><mtext>MeV</mtext></mrow></msubsup><mi>σ</mi><mrow><mo>(</mo><mi>E</mi><mo>)</mo></mrow><mo> </mo><mi>ϕ</mi><mrow><mo>(</mo><mi>E</mi><mo>)</mo></mrow><mtext>d</mtext><mi>E</mi></mrow><mrow><msubsup><mstyle mathsize="140%" displaystyle="true"><mo>∫</mo></mstyle><mrow><mn>10</mn><mo> </mo><mtext>MeV</mtext></mrow><mrow><mn>24</mn><mo> </mo><mtext>MeV</mtext></mrow></msubsup><mi>ϕ</mi><mrow><mo>(</mo><mi>E</mi><mo>)</mo></mrow><mtext>d</mtext><mi>E</mi></mrow></mfrac></mrow></math> where σ ( E ) represents the reaction cross-section of energy E , and φ ( E ) represents the energy-dependent flux. In this case, the bremsstrahlung radiation was calculated using the following equation: <math display="block" id="M15"><mrow><mi>ϕ</mi><mo>=</mo><mstyle displaystyle="true"><mrow><msubsup><mo>∫</mo><mrow><mn>10</mn><mo> </mo><mtext>MeV</mtext></mrow><mrow><mn>24</mn><mo> </mo><mtext>MeV</mtext></mrow></msubsup><mrow><mi>ϕ</mi><mrow><mo>(</mo><mi>E</mi><mo>)</mo></mrow><mtext>d</mtext><mi>E</mi><mo>.</mo></mrow></mrow></mstyle></mrow></math> 111 Ag production routes 1 Three nuclear reaction pathways were used by the nuclear reactor, cyclotron, and microtron RM-55, respectively, to produce 111 Ag as a β - -emitter in a no-carrier-added form: - 110 Pd(n,γ) 111 Pd <math id="M16"><mrow><mover><mo>→</mo><mrow><msup><mi>β</mi><mo>−</mo></msup></mrow></mover></mrow></math> 111 Ag [ 21 21 , 22 22 ] - 110Pd(d,n)111Ag [ 23 23 - 25 25 23-25 ] - natCd(γ,p)111Ag [ 28 28 ] - natIn(γ,α)111Ag The production methodology involves work in many different directions, such as nuclear data, irradiation technology, chemical separation, and product quality control. Production of 111 Ag by nat Pd(n,x) reactions 2 Palladium involves six stable isotopes of natural abundance; therefore, different radionuclides are produced by their activation using thermal neutrons in the nuclear reactor, as shown in Scheme 1 Scheme 1 . Activation of natural palladium targets by thermal neutrons produced 111,111m Pd as an intermediate radionuclide, as shown in the first nuclear reaction pathway. Nuclear data were obtained from literature data [ 42 42 - 46 46 42-46 ]. Scheme 1 Scheme 1 shows that 111 Ag can be produced by pathway (1) accompanied by 103 Pd and 109 Pd. In the case of 103 Pd, which decayed to 103 Rh by electron capture and could easily be separated by chemical methods. However, the parallel reaction for the production of 111 Ag using natural palladium is the neutron capture of 108 Pd to form 109 Pd, which eventually decays by β - emission into stable 109 Ag.  This reaction also limits the final specific activity of 111 Ag due to the high concentration of 109 Ag. Therefore, 111 Ag is produced as a carrier, according to the data provided in Table 3 Table 3 [ 21 21 , 47 47 ]. An increase in the irradiation time from 24h to 960h contributes to a decrease in the specific activity of 111 Ag from 90 to 24 GBq/mg due to an increase in 109 Ag resulting from the decay of the high 109 Pd activity level based on a high natural abundance of 108 Pd (26.46%) and a high neutron cross-section reaction (8.68 b). According to Alberto et al., 1992 [ 21 21 ], the average yield of 109 Pd is 1630 MBq at 3×10 13 n cm -2 s -1 of neutron flux for 26 h of irradiation time, followed by 72 h of cooling to produce 100 MBq of 111 Ag (1μg of Ag). The specific activity of 111 Ag was enhanced by decreasing the amount of 109 Ag, which could be accomplished by decreasing the cooling time and rapid chemical separation of 111 Ag from 109 Pd after EOB. However, the enriched 110 Pd could be used instead of the natural palladium to achieve a high specific activity for the production of 111 Ag carrier-free. However, this type of nuclear reaction is not preferred because of the high target price. 1 1 Irradiation time 4 1 AEOB 2 1 Amount (µg) 2 1 Aspect 1 1   2 1 109 Pd 2 1 111 Pd 1 1 109 Ag 1 1 111 Ag 1 1 (mCi/mg) 1 1 (GBq/mg) 1 1 (h) 1 1 (mCi) 1 1 (GBq) 1 1 (mCi) 1 1 (GBq) 1 1   1 1   1 1   1 1   1 1 24 1 1 1706 1 1 62.9 1 1 3.4 1 1 0.125 1 1 1.4 1 1 0.02 1 1 2430 1 1 90 1 1 48 1 1 2217 1 1 82 1 1 6.5 1 1 0.24 1 1 2.84 1 1 0.04 1 1 2290 1 1 85 1 1 72 1 1 2360 1 1 85 1 1 9.4 1 1 0.344 1 1 4.3 1 1 0.06 1 1 2190 1 1 80 1 1 96 1 1 2400 1 1 89 1 1 12 1 1 0.44 1 1 5.75 1 1 0.075 1 1 2051 1 1 76 1 1 144 1 1 2400 1 1 89 1 1 16.5 1 1 0.51 1 1 8.6 1 1 0.1 1 1 1896 1 1 70 1 1 192 1 1 2400 1 1 89 1 1 20.3 1 1 0.75 1 1 11.4 1 1 0.13 1 1 1760 1 1 65 1 1 240 1 1 2400 1 1 89 1 1 23.4 1 1 0.86 1 1 14.3 1 1 0.15 1 1 1620 1 1 60 1 1 480 1 1 2400 1 1 89 1 1 32.7 1 1 1.2 1 1 28.5 1 1 0.21 1 1 1140 1 1 42 1 1 960 1 1 2400 1 1 89 1 1 37.7 1 1 1.38 1 1 57 1 1 0.24 1 1 658 1 1 24 Production of 111 Ag by nat Pd(d, x) reactions 2 There are two long-lived states of the 111 Ag radioisotope: the ground state ( t 1/2 = 7.45 d) and the excited state of 111m Ag ( t 1/2 = 64.8 s), which decays to 111g Ag by IT (99.3%). Excitation studies have been performed to determine the potential to produce 111 Ag (theranostic applications) using deuteron-induced reactions on nat Pd [ 23 23 , 25 25 , 48 48 - 51 51 48-51 ]. The meta-stable and ground-state of 111 Ag is occupied by the beta-decay of meta-stable and ground-state of 111 Pd ( t 1/2 = 5.5 h and 23.4 min, respectively. Experimental excitation functions have been studied using deuteron-induced reactions on natural palladium [ 23 23 , 25 25 ], which have encountered diff iculties in 111 Ag production with high purity due to a variety of nuclear reactions that are synchronized with the main reaction (d,n), as shown in Table 4 Table 4 . Side nuclear reactions depend on the projectile energy (deuteron energy) to reach the reaction threshold energy and the abundance of each isotope. Table 4 Table 4 reveals that 111 Ag production uses a nat Pd(d,x) reaction based on a 110 Pd(d,n) reaction as a direct nuclear reaction. However, there are parallel reactions to 106m,105,104,103 Ag production that also consume the products of the 105 Pd(d,n), 104 Pd(d,n), 103 Pd(d,n), and 102 Pd(d,n) reactions, respectively. 104,103 Ag does not pose a problem because of their short half-lives and decay by electron capture and positron emission to yield stable 104 Pd and 103 Rh isotopes, which can be easily separated by chemical methods. The experimental cross-section data for 105,106m,110m,111 Ag indicated the presence of their cross sections with high values within the deuteron energy range of 5–25 MeV [ 25 25 , 51 51 ]. Half-lives of 110m Ag, 106m Ag and 105 Ag are longer than the 111 Ag half-life and are thus difficult to separate chemically. In the literature, experimental data for integral physical yields are rare and have only been found in Ditroi et al., 2012 [ 23 23 ], as shown in Fig. 3 Fig. 3 . 1 1 Product 1 1 t 1/2 1 1 Nuclear reaction 1 1 Q value(MeV) 1 1 E Th (MeV) 1 1 E deutron (MeV) 1 1 Cross section in mb (σ) 1 1 References 1 1 111 Ag 1 1 7.45 d 1 1 110 Pd (d, n) 1 1 4.9492 1 1 0 1 1 5.8 1 1 18.0±1.9 1 1 [ 25 25 ] 1 1   1 1   1 1   1 1   1 1   1 1 9 1 1 45.7±5.0 1 1   1 1   1 1   1 1   1 1   1 1 12.2 1 1 33.9±4.4 1 1   1 1   1 1   1 1   1 1   1 1 14.9 1 1 29.2±4.3 1 1   1 1   1 1   1 1   1 1   1 1 17.6 1 1 19.6±3.8 1 1   1 1   1 1   1 1   1 1   1 1 22 1 1 15.0±2.5 1 1 110m Ag 1 1 249.83 d 1 1   1 1   1 1   1 1 5.8 1 1 0.7±0.1 1 1 [ 25 25 ] 1 1   1 1   1 1   1 1   1 1   1 1 9 1 1 16.6±1.5 1 1   1 1   1 1   1 1   1 1   1 1 12.2 1 1 36.7±3.4 1 1   1 1   1 1 110 Pd (d,2n) 1 1 -3.8807 1 1 3.952 1 1 14.9 1 1 40.8±3.8 1 1   1 1   1 1   1 1   1 1   1 1 17.6 1 1 27.7±2.8 1 1   1 1   1 1   1 1   1 1   1 1 20 1 1 19.2±2.1 1 1   1 1   1 1   1 1   1 1   1 1 22 1 1 13.0±1.5 1 1 106m Ag 1 1 8.28 d 1 1 105 Pd (d,n) 1 1 3.5889 1 1 0 1 1 5.8 1 1 3.2±0.3 1 1 [ 25 25 ] 1 1   1 1   1 1 106 Pd (d,2n) 1 1 -5.9721 1 1 6.086 1 1 9 1 1 29.8±2.5 1 1   1 1   1 1 108 Pd (d,4n) 1 1 -21.731 1 1 22.137 1 1 12.2 1 1 76.8±6.4 1 1   1 1   1 1 110 Pd (d,6n) 1 1 -36.681 1 1 37.353 1 1 14.9 1 1 114.8±9.5 1 1   1 1   1 1   1 1   1 1   1 1 17.6 1 1 116.2±9.6 1 1   1 1   1 1   1 1   1 1   1 1 20 1 1 81.5±6.8 1 1   1 1   1 1   1 1   1 1   1 1 22 1 1 46.9±3.9 1 1   1 1   1 1   1 1   1 1   1 1 22.2 1 1 51.6±4.3 1 1   1 1   1 1   1 1   1 1   1 1 23.8 1 1 34.6±2.9 1 1 105 Ag 1 1 41.29 d 1 1 104 Pd (d,n) 1 1 2.74 1 1 0 1 1 5.8 1 1 20.2±1.6 1 1 [ 25 25 ] 1 1   1 1   1 1 105 Pd (d,2n) 1 1 -4.354 1 1 4.438 1 1 9 1 1 186.0±14.6 1 1   1 1   1 1 106 Pd (d,3n) 1 1 -13.915 1 1 14.180 1 1 12.2 1 1 251.2±19.7 1 1   1 1   1 1 108 Pd (d,5n) 1 1 -29.674 1 1 30.228 1 1 14.9 1 1 293.0±23.0 1 1   1 1   1 1 110 Pd (d,7n) 1 1 -44.624 1 1 45.441 1 1 17.6 1 1 336.3±26.4 1 1   1 1   1 1   1 1   1 1   1 1 20 1 1 344.4±27.1 1 1   1 1   1 1   1 1   1 1   1 1 22 1 1 292.5±23.0 1 1 104 Ag 1 1 69.2 m 1 1 104 Pd (d,2n) 1 1 -7.286 1 1 7.427 1 1 7.6 1 1 3.0±1.0 1 1 [ 24 24 ] 1 1   1 1   1 1 105 Pd (d,3n) 1 1 -14.38 1 1 14.656 1 1 9.5 1 1 9.0±2.0 1 1   1 1   1 1 106 Pd (d,4n) 1 1 -23.941 1 1 24.396 1 1 10 1 1 25.0±4.0 1 1   1 1   1 1 108 Pd (d,6n) 1 1 -39.7 1 1 40.441 1 1 11.4 1 1 38.0±6.0 1 1   1 1   1 1 110 Pd (d,8n) 1 1 -54.649 1 1 55.651 1 1 11.8 1 1 46.0±7.0 1 1   1 1   1 1   1 1   1 1   1 1 12.6 1 1 45.0±6.0 1 1   1 1   1 1   1 1   1 1   1 1 13.8 1 1 59.0±8.0 1 1   1 1   1 1   1 1   1 1   1 1 15 1 1 63.0±9.0 1 1   1 1   1 1   1 1   1 1   1 1 17 1 1 88.0±10.0 1 1   1 1   1 1   1 1   1 1   1 1 18.1 1 1 101.0±13.0 1 1   1 1   1 1   1 1   1 1   1 1 20.3 1 1 128.0±13.0 1 1 103 Ag 1 1 65.7 m 1 1 102 Pd (d,n) 1 1 1.964 1 1 0 1 1 5.8 1 1 0.6±0.1 1 1 [ 25 25 ] 1 1   1 1   1 1 104 Pd (d,3n) 1 1 -15.671 1 1 15.974 1 1 9 1 1 3.6±0.4 1 1   1 1   1 1 105 Pd (d,4n) 1 1 -22.765 1 1 23.202 1 1 12.2 1 1 2.0±0.3 1 1   1 1   1 1 106 Pd (d,5n) 1 1 -32.326 1 1 32.94 1 1 14.9 1 1 1.5±0.3 1 1   1 1   1 1 108 Pd (d,7n) 1 1 -48.085 1 1 48.983 1 1 17.6 1 1 3.3±0.4 1 1   1 1   1 1 110 Pd (d,9n) 1 1 -63.034 1 1 64.189 1 1 20 1 1 22.9±2.4 1 1   1 1   1 1   1 1   1 1   1 1 22 1 1 34.5±3.6 1 1   1 1   1 1   1 1   1 1   1 1 23.8 1 1 47.3±4.9 1 1   Furthermore, as shown in Table 5 Table 5 , 111 Ag can be produced indirectly via nat Pd(d, x) on the basis of a 110 Pd(d, p) reaction to produce 111 Pd, which decays by beta-emission to 111 Ag. The deutreon-induced reaction for 108 Pd via (d, p) produces 109 Pd, which decays by beta emission to stable 109 Ag, reducing the specific activity of 111 Ag. Although the cross-section values for the production of 109 Pd via nat Pd (d, p) are high [ 23 23 ], there is no documented existence of 109 Ag in the literature. 1 1 Product 1 1 t 1/2 1 1 Nuclear reaction 1 1 Q value(MeV) 1 1 E Th (MeV) 1 1 E deutron (MeV) 1 1 Cross section in mb (σ) 1 1 Refs. 1 1 111m Pd 1 1 5.5 h 1 1 110 Pd (d, p) 1 1 3.502 1 1 0 1 1 5.8 1 1 1.3±0.14 1 1 [ 23 23 ] 1 1   1 1   1 1   1 1   1 1   1 1 9.5 1 1 2.36±0.32 1 1   1 1   1 1   1 1   1 1   1 1 12.6 1 1 2.97±0.49 1 1   1 1   1 1   1 1   1 1   1 1 15 1 1 2.51±0.39 1 1   1 1   1 1   1 1   1 1   1 1 18.2 1 1 3.3±0.4 1 1   1 1   1 1   1 1   1 1   1 1 22.3 1 1 3±0.4 1 1   1 1   1 1   1 1   1 1   1 1 26 1 1 1.9±0.3 1 1 109 Pd 1 1 13.7 h 1 1 108 Pd (d,p) 1 1 3.929 1 1 0 1 1 5.8 1 1 24.4±2.6 1 1 [ 23 23 ] 1 1   1 1   1 1 110 Pd (d,p2n) 1 1 -11.02 1 1 11.22 1 1 9.5 1 1 63.4±6.9 1 1   1 1   1 1 110 Pd (d, 3 He) 109 Rh 1 1 -5.127 1 1 5.22 1 1 12.6 1 1 52.9±5.7 1 1   1 1   1 1   1 1   1 1   1 1 15 1 1 46.6±5.1 1 1   1 1   1 1   1 1   1 1   1 1 18.2 1 1 38±4.4 1 1   1 1   1 1   1 1   1 1   1 1 22.3 1 1 27.7±3.3 1 1   1 1   1 1   1 1   1 1   1 1 26 1 1 36.6±4.3 1 1 101 Pd 1 1 8.47 h 1 1 102 Pd (d,p2n) 1 1 -12.767 1 1 13.019 1 1 13.3 1 1 0.57±0.07 1 1 [ 23 23 ] 1 1   1 1   1 1 104 Pd (d,p4n) 1 1 -30.401 1 1 30.991 1 1 22.3 1 1 0.91±0.11 1 1   1 1   1 1 105 Pd (d,p5n) 1 1 -37.496 1 1 38.218 1 1 29.3 1 1 7.43±0.83 1 1   1 1   1 1 106 Pd (d,p6n) 1 1 -47.057 1 1 47.951 1 1 32.3 1 1 8.56±0.95 1 1   1 1   1 1 108 Pd (d,p8n) 1 1 -62.816 1 1 63.988 1 1 37.8 1 1 4.25±0.48 1 1 100 Pd 1 1 3.63 d 1 1 102 Pd (d,p3n) 1 1 -2.106 1 1 2.1474 1 1 5.8 1 1 0.1±0.01 1 1 [ 23 23 ] 1 1   1 1   1 1 104 Pd (d,p5n) 1 1 -38.672 1 1 39.442 1 1 9.5 1 1 0.52±0.06 1 1   1 1   1 1 105 Pd (d,p6n) 1 1 -45.786 1 1 46.665 1 1 12.6 1 1 1.16±0.13 1 1   1 1   1 1   1 1   1 1   1 1 15 1 1 0.77±0.08 1 1   1 1   1 1   1 1   1 1   1 1 18.2 1 1 7.66±0.96 1 1   1 1   1 1   1 1   1 1   1 1 22.3 1 1 3.49±0.46 1 1   1 1   1 1   1 1   1 1   1 1 26 1 1 2.06±0.27 1 1   Production of 111 Ag based on nat Cd(γ,x) reactions 2 Figure 4 Figure 4 indicates that the maximum cross sections of (γ, n) and (γ, p) reactions on natural cadmium within the gamma energy range of 15–20 MeV are 200–250 mb [ 52 52 ]. Table 6 Table 6 provides the threshold energies for various photon reactions to cadmium isotopes, which clarified that both (γ, n) and (γ, p) reactions begin within the energy range of 7–11 MeV, whereas the photon energy produced and required for the reaction to occur is within the range of 15–20 MeV, which is greater than the threshold energies for these reactions. Therefore, the generated γ-ray energy was able to produce all the radionuclides established in Table 6 Table 6 [ 28 28 , 30 30 , 53 53 - 54 54 53-54 ], as verified by the relative yield measurements for these radionuclides [ 28 28 ]. 111 Ag is difficult to produce through nat Cd(γ, x) reactions because of simultaneous nuclear reactions that produce 105, 107, 109, 110m, 112, 113, 115 Ag based on the direct reactions (γ, p) cadmium isotopes at the same γ-energy used. In contrast, there are parallel reactions based on indirect reactions such as 108 Cd(γ, n) and 110 Cd(γ, n) which produce 107 Cd and 109 Cd. These two isotopes which decay by electron capture to 107 Ag and 109 Ag stable isotopes. These two Ag isotopes decrease the specific activity of 111 Ag. The literature has not definitively indicated the presence of silver isotopes, whether long-lived radioactive, such as 105 Ag, 110m Ag, or stable silver isotopes such as 107 Ag and 109 Ag, and concentrations can influence the specific activity of 111 Ag. 1 1 Target 1 1 Abundance (%) 1 1 Product 1 1 t 1/2 1 1 Nuclear reaction 1 1 Q value(MeV) 1 1 E Th (MeV) 1 1 Relative reaction yield 1 1 Ref. 1 1 106 Cd 1 1 1.25 1 1 105 Ag 1 1 41.29d 1 1 106 Cd(γ,p) 1 1 -7.35 1 1 7.35 1 1 0.47 ± 0.06 1 1 [ 30 30 ] 1 1   1 1   1 1 105 Cd 1 1 55.5 m 1 1 106 Cd(γ,n) 1 1 -10.87 1 1 10.67 1 1   1 1 [ 28 28 ] 1 1 108 Cd 1 1 0.89 1 1 107 Ag 1 1 Stable 1 1 108 Cd(γ,p) 1 1 -8.135 1 1 8.135 1 1 1.15±0.08 1 1 [ 28 28 ] 1 1   1 1   1 1 107 Cd 1 1 6.5 h 1 1 108 Cd(γ,n) 1 1 -10.334 1 1 10.334 1 1 110 Cd 1 1 12.49 1 1 109 Ag 1 1 Stable 1 1 110 Cd (γ,p) 1 1 -8.9175 1 1 8.9179 1 1   1 1 [ 28 28 ] 1 1   1 1   1 1 109 Cd 1 1 462.6 d 1 1 110 Cd (γ,n) 1 1 -9.915 1 1 9.915 1 1   1 1   1 1 110m Ag 1 1 249.83 d 1 1 111 Cd (γ,p) 1 1 -9.084 1 1 9.084 1 1 111 Cd 1 1 12.8 1 1 110 Cd 1 1 Stable 1 1 111 Cd (γ,n) 1 1 -6.9756 1 1 6.976 1 1 0.0062 ± 0.0004 1 1 [ 28 28 ] 1 1 112 Cd 1 1 24.07 1 1 111 Ag 1 1 7.45 d 1 1 112 Cd (γ,p) 1 1 -9.648 1 1 9.648 1 1 0.035±0.002 1 1 [ 30 30 ] 1 1   1 1   1 1 111 Cd 1 1 Stable 1 1 112 Cd (γ,n) 1 1 -9.3939 1 1 9.3944 1 1   1 1 [ 50 50 ] 1 1 113 Cd 1 1 12.26 1 1 112 Ag 1 1 3.13 h 1 1 113 Cd (γ,p) 1 1 -9.749 1 1 9.749 1 1 0.0062 ± 0.0004 1 1 [ 30 30 ] 1 1   1 1   1 1 112 Cd 1 1 Stable 1 1 113 Cd (γ,n) 1 1 -6.5397 1 1 6.5399 1 1   1 1 [ 28 28 ] 1 1 114 Cd 1 1 28.73 1 1 113 Ag 1 1 5.37 h 1 1 114 Cd (γ,p) 1 1 -10.277 1 1 10.278 1 1 0.037 ± 0.005 1 1 [ 30 30 ] 1 1   1 1   1 1 113 Cd 1 1 Stable 1 1 114 Cd (γ,n) 1 1 -9.043 1 1 9.0434 1 1   1 1 [ 28 28 ] 1 1 116 Cd 1 1 7.58 1 1 115 Ag 1 1 20 m 1 1 116 Cd (γ,p) 1 1 -11.019 1 1 11.02 1 1 0.017 ± 0.002 1 1 [ 28 28 ] 1 1   1 1   1 1 115 Cd 1 1 53.46 1 1 116 Cd (γ,n) 1 1 -8.699 1 1 8.6997 1 1   1 1 [ 29 29 ] Production of 111 Ag based on nat In(γ,x) reactions 2 Table 7 Table 7 indicates that 111 Ag may be produced by the nat In(γ, x ) based on the 115 In(γ, α) reaction when the photon energy is greater than the sum of the two energies of the threshold and the Coulomb barrier (14.1 MeV). Other channels, such as the (γ, n) and (γ, p) reactions, are opened at threshold energies of 9 and 6.8 MeV, respectively, less than that required for the (γ, α) reaction, to produce 114m In ( t 1/2 = 49.51 d) and the stable 114 Cd isotope, which can be easily separated by chemical methods. Parallel nuclear reactions produce a stable isotope of 109 Ag, a radionuclide of 112m In ( t 1/2 = 20.56 min) and a stable isotope of 112 Cd, based on the reactions of 113 In(γ, α), (γ, n), and (γ, p), respectively. Fortunately, 113 In has a small abundance (4.3%) compared to 115 In (95.7%), so the 109 Ag concentration produced will not be a concern, as in other nuclear reactions. 1 1 Target 1 1 Abundance(%) 1 1 Product 1 1 t 1/2 1 1 Nuclear reaction 1 1 Q value(MeV) 1 1 E th (MeV) 1 1 B c (MeV) 1 1 115 In 1 1 95.7 1 1 111 Ag 1 1 7.45 d 1 1 115 In(γ,α) 1 1 -3.746 1 1 3.746 1 1 10.34 1 1   1 1   1 1 114 Cd 1 1 Stable 1 1 115 In(γ,p) 1 1 -6.81 1 1 6.811 1 1   1 1   1 1 114m In 1 1 49.51 d 1 1 115 In(γ,n) 1 1 -9.038 1 1 9.038 1 1   1 1   1 1 113m Cd 1 1 14.1 y 1 1 115 In(γ,pn) 1 1 -15.853 1 1 15.85 1 1 115 In 1 1 4.3 1 1 109 Ag 1 1 Stable 1 1 113 In(γ,α) 1 1 -3.072 1 1 3.073 1 1 10.35 1 1   1 1   1 1 112 Cd 1 1 Stable 1 1 113 In(γ,p) 1 1 -6.081 1 1 6.081 1 1   1 1   1 1 112m In 1 1 20.56 m 1 1 113 In(γ,n) 1 1 -9.448 1 1 9.449 1 1   1 1   1 1 111m Cd 1 1 48.54 m 1 1 113 In(γ,pn) 1 1 -15.475 1 1 15.475 1 1   Figure 5 Figure 5 shows the energy distributions of bremsstrahlung radiation, as quoted in the energy range of interest. The integrations in Eq. (5) for the effective cross section of 113 In and 115 In were calculated using the data in Figs. 4 Figs. 4 and 5 (0.00532 and 0.00432 barns, respectively). In addition, the bremsstrahlung radiation flux in the range of concern was assessed, producing 10.37% of the overall bremsstrahlung radiation, as summarized in Table 8 Table 8 . 1 1 Data/result 1 1 131 In 1 1 115 In 1 1 Abundance 1 1 0.0429 1 1 0.9571 1 1 (γ,α) reaction <math id="M17"><mrow><mo> </mo><msub><mi>σ</mi><mrow><mstyle mathvariant="bold" mathsize="normal"><mi>e</mi><mi>f</mi><mi>f</mi></mstyle></mrow></msub></mrow></math> (barns) 1 1 0.00532 1 1 0.00432 1 1 <math id="M18"><mi>ϕ</mi></math> 10Mev < E < 24 MeV (cm -2 s -1 ) 1 1 5.7 × 10 13 1 1 Interaction rate per gram of In (s -1 ) 1 1 6.94× 10 7 1 1 1.24 × 10 9 1 1 Product isotope 1 1 109 Ag 1 1 111 Ag 1 1 Half-life (days) 1 1 Stable 1 1 7.45 1 1 Production rate per gram of In (atom s -1 ) 1 1 6.94× 10 7 1 1 1.24 × 10 9 The bremsstrahlung photon flux in the range of interest will be 5.7 × 10 13 cm -2 s -1 if the electron accelerator is set to 10 μA [ 40 40 , 41 41 ]. Substituting the evaluated results in equation (2), the interaction rates for both nuclides per gram of target (6.94 × 10 7 and 1.24 × 10 9 s -1 , respectively) are calculated, as shown in Table 8 Table 8 . Since the (γ,α) reactions of 113 In and 115 In produce 109Ag and 111 Ag, respectively, the rate of 109 Ag production to the rate of 111 Ag production is approximately 1:18. The generated activity of 111 Ag was calculated as a function of irradiation time by substituting the interaction rate of 115 In in equation (1), as shown in Fig. 6 Fig. 6 . Conclusion 1 This study confirms that the available nuclear reactions, which rely on natural targets to minimize production costs using Pd and Cd targets by the nat Pd(n, x), nat Pd(d, x), and nat Cd(γ, x) reactions, based on the 110 Pd(n, γ), 110 Pd(d, n), and 112 Cd(γ, n) reactions, respectively, to produce 111 Ag have several issues. 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This research was funded by the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University through a fast-track research funding program. 10.1007/s41365-022-00991-6 Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB). 2021-09-03 2021-12-02 2021-12-03 2022-02-03 2022-03-18 © China Science Publishing & Media Ltd. (Science Press), Shanghai Institute of Applied Physics, the Chinese Academy of Sciences, ChineseNuclear Society and Springer Nature Singapore Pte Ltd. 2022 This is a post-peer-review, pre-copyedit version of an article published in Nuclear Science and Techniques. The final authenticated version is available online at: http://dx.doi.org/10.1007/s41365-022-00991-6 http://dx.doi.org10.1007/s41365-022-00991-6 . 2022 Nuclear Science and Techniques 02 33