Dose reconstruction with Compton camera during proton therapy via subset-driven origin ensemble and double evolutionary algorithm

Zhi-Yang Yao; Yong-Shun Xiao; Ji-Zhong Zhao

doi:10.1007/s41365-023-01207-1

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Dose reconstruction with Compton camera during proton therapy via subset-driven origin ensemble and double evolutionary algorithm

NUCLEAR PHYSICS AND INTERDISCIPLINARY RESEARCH | Updated：2023-06-07

- Dose reconstruction with Compton camera during proton therapy via subset-driven origin ensemble and double evolutionary algorithm
- Dose reconstruction with Compton camera during proton therapy via subset-driven origin ensemble and double evolutionary algorithm
- 核技术（英文版） 2023年34卷第4期文章编号：59
- Affiliations：
  
  1.Department of Engineering Physics, Tsinghua University, Beijing 100084, China
  2.Key Laboratory of Particle & Radiation Imaging (Tsinghua University), Ministry of Education, Beijing 100084, China
- Author bio：
  
  † xiaoysh@mail.tsinghua.edu.cn
- Funds：
  
  Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation)(7191005)
- DOI：10.1007/s41365-023-01207-1
  中图分类号：
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Dose reconstruction with Compton camera during proton therapy via subset-driven origin ensemble and double evolutionary algorithm[J]. 核技术（英文版）, 2023,34(4):59

Zhi-Yang Yao, Yong-Shun Xiao, Ji-Zhong Zhao. Dose reconstruction with Compton camera during proton therapy via subset-driven origin ensemble and double evolutionary algorithm[J]. Nuclear Science and Techniques, 2023,34(4):59
Dose reconstruction with Compton camera during proton therapy via subset-driven origin ensemble and double evolutionary algorithm[J]. 核技术（英文版）, 2023,34(4):59 DOI： 10.1007/s41365-023-01207-1.

Zhi-Yang Yao, Yong-Shun Xiao, Ji-Zhong Zhao. Dose reconstruction with Compton camera during proton therapy via subset-driven origin ensemble and double evolutionary algorithm[J]. Nuclear Science and Techniques, 2023,34(4):59 DOI： 10.1007/s41365-023-01207-1.

摘要

Abstract

Compton camera-based prompt gamma (PG) imaging has been proposed for range verification during proton therapy. However, a deviation between the PG and dose distributions, as well as the difference between the reconstructed PG and exact values, limit the effectiveness of the approach in accurate range monitoring during clinical applications. The aim of the study was to realize a PG-based dose reconstruction with a Compton camera, thereby further improving the prediction accuracy of in-vivo range verification and providing a novel method for beam monitoring during proton therapy. In this paper, we present an approach based on a subset-driven origin ensemble with resolution recovery and a double evolutionary algorithm to reconstruct the dose depth profile (DDP) from the gamma events obtained by a Cadmium-Zinc-Telluride Compton camera with limited position and energy resolution. Simulations of proton pencil beams with clinical particle rate irradiating phantoms made of different materials and the CT-based thoracic phantom were used to evaluate the feasibility of the proposed method. The results show that for the monoenergetic proton pencil beam irradiating homogeneous-material box phantom, the accuracy of the reconstructed DDP was within 0.3 mm for range prediction and within 5.2% for dose prediction. In particular, for 1.6-Gy irradiation in the therapy simulation of thoracic tumors, the range deviation of the reconstructed spread-out Bragg peak was within 0.8 mm, and the relative dose deviation in the peak area was less than 7% compared to the exact values. The results demonstrate the potential and feasibility of the proposed method in future Compton-based accurate dose reconstruction and range verification during proton therapy.

关键词

Keywords

Prompt gamma imagingDose reconstructionRange verificationOrigin ensembleCompton cameraEvolutionary algorithm

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