Aperture shape optimization in intensity-modulated radiation therapy planning

Li-Yuan Zhang; Zhi-Guo Gui; Peng-Cheng Zhang; Jie Yang

doi:10.1007/s41365-023-01300-5

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Aperture shape optimization in intensity-modulated radiation therapy planning

NUCLEAR PHYSICS AND INTERDISCIPLINARY RESEARCH | Updated：2023-10-13

- Aperture shape optimization in intensity-modulated radiation therapy planning
- Aperture shape optimization in intensity-modulated radiation therapy planning
- 核技术（英文版） 2023年34卷第9期文章编号：140
- Affiliations：
  
  1.Shanxi Provincial Key Laboratory for Biomedical Imaging and Big Data, North University of China, Taiyuan 030051, China
  2.School of Medicine Management, Shanxi University of Chinese Medicine, Taiyuan 030619, China
- Author bio：
  
  † good0806@sina.cn
- Funds：
  
  Natural Science Foundation of Shanxi Province(20210302124403);Research Project Supported by Shanxi Scholarship Council of China(2021-111);Science and Technology Innovation Project of Colleges and Universities in Shanxi Province(2022L353)
- DOI：10.1007/s41365-023-01300-5
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Aperture shape optimization in intensity-modulated radiation therapy planning[J]. 核技术（英文版）, 2023,34(9):140

Li-Yuan Zhang, Zhi-Guo Gui, Peng-Cheng Zhang, et al. Aperture shape optimization in intensity-modulated radiation therapy planning[J]. Nuclear Science and Techniques, 2023,34(9):140
Aperture shape optimization in intensity-modulated radiation therapy planning[J]. 核技术（英文版）, 2023,34(9):140 DOI： 10.1007/s41365-023-01300-5.

Li-Yuan Zhang, Zhi-Guo Gui, Peng-Cheng Zhang, et al. Aperture shape optimization in intensity-modulated radiation therapy planning[J]. Nuclear Science and Techniques, 2023,34(9):140 DOI： 10.1007/s41365-023-01300-5.

摘要

Abstract

The gradient element of the aperture gradient map is utilized directly to generate the aperture shape without modulation. This process can be likened to choosing the direction of negative gradient descent for the generic aperture shape optimization. The negative-gradient descent direction is more suitable under local conditions and has a slow convergence rate. To overcome these limitations, this study introduced conjugate gradients into aperture shape optimization based on gradient modulation. First, the aperture gradient map of the current beam was obtained for the proposed aperture shape optimization method, and the gradients of the aperture gradient map were modulated using conjugate gradients to form a modulated gradient map. The aperture shape was generated based on the modulated gradient map. The proposed optimization method does not change the optimal solution of the original optimization problem but changes the iterative search direction when generating the aperture shape. The performance of the proposed method was verified using cases of head and neck cancer, and prostate cancer. The optimization results indicate that the proposed optimization method better protects the organs at risk and rapidly reduces the objective function value by ensuring a similar dose distribution to the planning target volume. Compared to the contrasting methods, the normal tissue complication probability obtained by the proposed optimization method decreased by up to 4.61%, and the optimization time of the proposed method decreased by 5.26% on average for ten cancer cases. The effectiveness and acceleration of the proposed method were verified through comparative experiments. According to the comparative experiments, the results indicate that the proposed optimization method is more suitable for clinical applications. It is feasible for the aperture shape optimization involving the proposed method.

关键词

Keywords

Aperture shapeColumn generationConjugate gradientGradient modulationDirect aperture optimization

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