Preparation of the radioactive source core of iodine-125 seed

RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE

Preparation of the radioactive source core of iodine-125 seed

HE Jiaheng，

JIANG Lin，

LI Xingliang，

ZHONG Wenbin，

WANG Jing，

MA Zongping，

JIAN Yuan

Nuclear Science and Techniques

Vol.20, No.4

pp.231-234

Published in print 20 Aug 2009

DOI：10.13538/j.1001-8042/nst.20.231-234

42800

Iodine-125 seed is widely used in brachytherapy of intraocular tumors, brain tumors, and prostate cancer. The ¹²⁵I seed is prepared by depositing ¹²⁵I on a silver rod. This work was aimed at investigating effects of different parameters on the iodine adsorption, so as to optimize the process for preparing ¹²⁵I core of the seed. The parameters investigated include kind and concentration of halogenation reagent, halogenation time, adsorption time, pH and carrier iodine quantity.

125IAdsorptionSeed source

References

[1]

He J H, Luo S Z, Jiang S B,et al. Nucl Sci Tech, 2007, 6: 1-5.

[2]

Battermann JJ. Radiother Oncol, 2000, 57: 269-272.

[3]

Dicker A P, Lin C C, Leeper D B, et al. Semin Urol Oncol, 2000, 18: 152-159.

[4]

Nath S, Chen Z, Yue N, et al. Med Phys, 2000, 27: 1058-1066.

[5]

Zelefsky M J. Int J RadiatOncol Biol Phys, 2000, 48: 601-608.

[6]

Wu A, Lee C C, Johnson M, et al. Int J Radiat Oncol Biol Phys, 2000, 47: 1397-1403.

[7]

Li Z. Med Phys, 2001, 28: 1410-1415.

[8]

Xie D Y, Zhang Z C, Luo X Y. Acad J Sec Mil Med Univ. 2000, 21: 174-176.

[9]

Martinez-Monge R, Nag S, Nieroda C A, et al. Cancer, 1999, 85: 1218-1225.

[10]

Zelefsky M J. Cancer J, 2000, 6: 249-255.

[11]

Henkel T O, Kahmann F. Arch Ital Urol Androl, 2000, 72: 295-301.

[12]

Nath R, Meigooni A S, Nath R. Med Phys, 1990, 17: 1032-1040.

[13]

Manolkar R B, Sane S U, Pillai K T, et al. Appl Radiat Isot, 2003, 59: 145-150.

[14]

Mathew C, Majali M A, Balakrishnan S A. Appl Radiat Isot, 2002, 57: 359-367.

[15]

Ling C C. Int Radiat Oncol Biol Phys, 1992, 23: 81-86

[16]

Nath R, Meigooni A S, Muench P, et al. Med Phys, 1993, 20: 1465-1473.

[17]

Williamson J F, Quitero F. Med Phys, 1988, 15: 891-897.