Synthesis of serotonin transporter imaging agent [125I]ADAM

RADIOCHEMISTRY, RADIOPHARMACEOTICALS AND NUCLEAR MEDICINE

Synthesis of serotonin transporter imaging agent [¹²⁵I]ADAM

LU Chun-Xiong，

WU Chun-Ying，

JIANG Quan-Fu，

CHEN Zheng-Ping，

ZHANG Tong-Xing，

LI Xiao-Ming，

WANG Song-Pei

Nuclear Science and Techniques

Vol.16, No.3

pp.153-155

Published in print 01 Jun 2005

CLC：R817

33200

The synthesis of serotonin transporter imaging agent [¹²⁵I] -2-((2-((dimethylamino)methyl)phenyl) thio)-5-iodophenylamine([¹²⁵I] ADAM) was reported. The chemical structure of the labeling precursor 5- (tributylstannyl) -2-((2-((dimethylamino)methyl)phenyl)thio)phenylamine and all its intermediates were verified by IR,¹HNMR and MS. The radioiodinated compound was prepared using iododestannylation reaction by hydrogen peroxide. Final radiochemical purity was above 95% determined by TLC.

Serotonin transporter[125I] ADAMSynthesis

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