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Preparation of the radioactive source core of iodine-125 seed

RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE

Preparation of the radioactive source core of iodine-125 seed

HE Jiaheng
JIANG Lin
LI Xingliang
ZHONG Wenbin
WANG Jing
MA Zongping
JIAN Yuan
Nuclear Science and TechniquesVol.20, No.4pp.231-234Published in print 20 Aug 2009
42900

Iodine-125 seed is widely used in brachytherapy of intraocular tumors, brain tumors, and prostate cancer. The 125I seed is prepared by depositing 125I on a silver rod. This work was aimed at investigating effects of different parameters on the iodine adsorption, so as to optimize the process for preparing 125I core of the seed. The parameters investigated include kind and concentration of halogenation reagent, halogenation time, adsorption time, pH and carrier iodine quantity.

125IAdsorptionSeed source
References
[1] He J H, Luo S Z, Jiang S B,et al. Nucl Sci Tech, 2007, 6: 1-5.
[2] Battermann JJ. Radiother Oncol, 2000, 57: 269-272.
[3] Dicker A P, Lin C C, Leeper D B, et al. Semin Urol Oncol, 2000, 18: 152-159.
[4] Nath S, Chen Z, Yue N, et al. Med Phys, 2000, 27: 1058-1066.
[5] Zelefsky M J. Int J RadiatOncol Biol Phys, 2000, 48: 601-608.
[6] Wu A, Lee C C, Johnson M, et al. Int J Radiat Oncol Biol Phys, 2000, 47: 1397-1403.
[7] Li Z. Med Phys, 2001, 28: 1410-1415.
[8] Xie D Y, Zhang Z C, Luo X Y. Acad J Sec Mil Med Univ. 2000, 21: 174-176.
[9] Martinez-Monge R, Nag S, Nieroda C A, et al. Cancer, 1999, 85: 1218-1225.
[10] Zelefsky M J. Cancer J, 2000, 6: 249-255.
[11] Henkel T O, Kahmann F. Arch Ital Urol Androl, 2000, 72: 295-301.
[12] Nath R, Meigooni A S, Nath R. Med Phys, 1990, 17: 1032-1040.
[13] Manolkar R B, Sane S U, Pillai K T, et al. Appl Radiat Isot, 2003, 59: 145-150.
[14] Mathew C, Majali M A, Balakrishnan S A. Appl Radiat Isot, 2002, 57: 359-367.
[15] Ling C C. Int Radiat Oncol Biol Phys, 1992, 23: 81-86
[16] Nath R, Meigooni A S, Muench P, et al. Med Phys, 1993, 20: 1465-1473.
[17] Williamson J F, Quitero F. Med Phys, 1988, 15: 891-897.