Preventive role of palladium-103 radioactive stent on in-stent restenosis in rabbit iliac arteries

RADIOCHEMISTRY RADIOPHARMACEOTICALS AND NUCLEAR MEDICINE

Preventive role of palladium-103 radioactive stent on in-stent restenosis in rabbit iliac arteries

LUO Quan-Yong，

CHEN Li-Bo，

YUAN Zhi-Bin，

LU Han-Kui，

ZHU Rui-Sen

Nuclear Science and Techniques

Vol.16, No.1

pp.35-39

Published in print 01 Feb 2005

CLC：R817.5

26400

The abilility of γ-emitting palladium-103 stent implantation to inhibit in-stent restenosis in rabbit iliac arteries was investigated. Quantitative histomorphometry of the stented iliac segments 28 days after the implantation indicated that palladium-103 stents made a significant reduction in neointimal area and percent area stenosis compared with the nonradioactive stents. Lumen area in the palladium-103 stents treatment group was larger than the control group. However, the reduction of neointima formation by palladium-103 stents implantation was in a non-dose-dependent fashion. Low ionizing radiation doses via γ-emitting palladium-103 stent are effective in preventing neointimal hyperplasia in iliac arteries of rabbits. Palladium-103 stents can be employed as a possible novel means to prevent in-stent restenosis.

RestenosisPalladium-103RadiationStentRadioisotopes

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