Synthesis and application of PLGA labeled with 125I

RADIOCHEMISTRY RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE

Synthesis and application of PLGA labeled with ¹²⁵I

HUA Nan，

SUN Jiao

Nuclear Science and Techniques

Vol.17, No.1

pp.48-52

Published in print 20 Feb 2006

DOI：10.1016/S1001-8042(06)60011-0

CLC：Q819

30000

The weight loss in vivo degradation of poly (lactide-co-glycolide) (PLGA) radiolabeled with ¹²⁵I was investigated. PLGA with molecular weight (M_w) of 84000(LA/GA=85/15) were labeled with ¹²⁵I in the chloroform media by circularly heating and round films of about 15mm in diameter were formed. The composition and M_w of the ¹²⁵I-PLGA were characterized by ¹H-NMR and viscosimeter. The weight loss of this copolymer in vitro and in vivo degradation was quantified by determining radioactivity of materials. The results indicated that PLGA exhibited significantly faster degradation in vivo than that of in vitro conditions.

Poly (lactide-co-glycolide)125I labelingDegradation

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