Preparation and properties of 117mSn(Ⅳ)-TTHMP in in-vitro and in small animals

RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE

Preparation and properties of ^117mSn(Ⅳ)-TTHMP in in-vitro and in small animals

HE Jiaheng，

LUO Shunzhong，

JIANG Shubin，

YANG Yuqing，

WANG Guanquan

Nuclear Science and Techniques

Vol.18, No.6

pp.344-348

Published in print 20 Dec 2007

DOI：10.1016/S1001-8042(08)60005-6

CLC：R817.8,R738.1

34400

In this work, TTHMP was synthesized and labelled with ^117m Sn. The preparation conditions, stability and lipophilicity of ^117mSn(IV)-TTHMP were investigated. Biodistribution of the complex in rabbits and mice was studied. It was found that the quantity of TTHMP and pH value of the prepararion solution had vital effects on the labeling yield of ^117mSn(IV)-TTHMP. It was also found that ^117mSn(IV)-TTHMP was hydrophilic and stable at room temperature and 37℃ in open air. ^117mSn(IV)-TTHMP showed unexpectedly high bone uptake and bone-to-blood ratio in the animals. This made it potentially useful as an reagent for skeletal scintigraphy and radiotherapy of bone tumors.

117mSnTTHMPBone tumorBiodistribution

References

[1]

Kaplan E, Fels I G, Kotlowski B R. J Nucl Med, 1960, 1: 1-13.

[2]

Maxon H R, Schroder L E, Thomas S R, et al. Radiology, 1990, 176: 155-159.

[3]

Srivastava S C, Suresh C, Meinken G E, et al.

Formulation for tin-117m diethylenetriaminepentaacetic acids

. United States patent: 6,604,532,1999.

Baidu Scholar

Google Scholar

[4]

Laing A H, Ackery D M, Bayly R J, et al. Br J Radiol, 1991, 64: 816-822.

[5]

Lewington V J, McEwan A J, Ackery D M, et al. Eur J Cancer, 1991, 27: 954-958.

[6]

Srivastava S C, Suresh C, Meinken G E, et al.

Radiopharmaceutical stannic Sn-117m chelate compositions and methods of use

. United States patent: 6,231,832,2001.

Baidu Scholar

Google Scholar

[7]

Atkins H L, Mausner L F, Srivastava S C, et al. Radiology, 1993, 186: 279-283.

[8]

YANG Yuqing, LUO Shunzhong, PU Manfei, et al. Appl Radiat Isot, 2005, 62: 597-603.

[9]

Krishinamurthy G T, Swailem F M, Walsh T K. The Journal of Nuclear Medicine, 1995, 117: 30.

[10]

Oster Z H, Som P, Srivastava S C, et al. Int J Nucl Med Biol, 1985, 12(3): 175-184.

[11]

WANG Liansheng, HAN Shuokui. Molecular structure, properties and activities. Beijing: Chemistry Industry Publishing Company, 1997.

[12]

Abrams M J, Murrer B R. Advances in metals in medicine. London: JAI Press Inc, 1993: 134-135.

[13]

Francis M D. Calcified Tissue International, 1969, (3): 151.