PREPARATION OF BONE TUMOR THERAPEUTIC RADIOPHARMACEUTICALS 153Sm-EDTMP

PREPARATION OF BONE TUMOR THERAPEUTIC RADIOPHARMACEUTICALS ¹⁵³Sm-EDTMP

Luo Shunzhong，

Pu Manfei，

Qiao Jian，

Liu Zhonglin，

Zhao Pengji，

Fu Yibei，

Deng Houfu

Nuclear Science and Techniques

Vol.6, No.3

pp.146-149

Published in print 01 Aug 1995

31100

Samarium-153-EDTMP (ethylene diamine tetramethylene phosphonate), for its promising biological properties, has been proved as a palliating therapeutic agent for bone tumor in human beings. ¹⁵³Sm with high radionuclear purity and specific activity of 5.18 GBq (140 mCi)/mg Sm₂O₃ was prepared by irradiating natural Sm₂O₃(¹⁵²Sm, 26.7%) sample, replacing costly enriched samarium oxide target, at a flux of 4x10¹³n·cm^-2·s^-1 for 110h. The yield of ¹⁵³Sm complexing with EDTMP is greater than 98%at pH 8〜10 in boiling water bath for 30 min, and not significantly decreases within one week after ¹⁵³Sm-EDTMP complex formation.

Bone tumorTherapeutic radiopharmaceuticals153Sm153Sm-EDTMP

References

Joshi D P, Seery W H, Goldberg L G et al. Jama, 1965; 193: 621

Reddy E K, Robinson R G, Mansfield C M. J Natl Med Assoc, 1986; 78: 27

Eisenhut M, Berberich R, Rimmig B et al. J Nucl Med, 1986; 27: 1255—1261

Ketring A. Nucl Med Biol, 1987; 14: 223—232