Preparation and primary biological evaluation of novel nitrido-188Re complexes/lipiodol

RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE

Preparation and primary biological evaluation of novel nitrido-¹⁸⁸Re complexes/lipiodol

WANG Guanquan，

WEI Hongyuan，

LUO Shunzhong，

HE Jiaheng，

YANG Yuqing，

WANG Wenjin，

XIONG Xiaoling

Nuclear Science and Techniques

Vol.19, No.4

pp.223-229

Published in print 20 Aug 2008

DOI：10.1016/S1001-8042(08)60054-8

CLC：R817

50800

Two new nitrido-¹⁸⁸Re complexes were prepared by a modified method in high yield. These complexes were stable in vitro. The biodistribution in normal mice showed that these nitrido-¹⁸⁸Re complexes could accumulate in liver and dissipate quickly from almost all organs. TAE was performed with the use of lipiodol solutions of two complexes to rabbit VX2 liver tumor models. SPECT images showed that the two lipiodol solutions could remain in tumor for about 9 h (¹⁸⁸ReN-NEPTDD/lipiodol) and 12 h (¹⁸⁸ReN-NEMMPTDD/lipiodol), respectively.

NitridoTDD derivativesLipiodolLiver cancer

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