A novel zoledronic acid derivative, 1-hydroxy-2-(2-propyl-1H-imidazol-1-yl)ethane-1,1-diyldiphosphonic acid (PIDP), was synthesized by three-step reactions from 2-propyl-1H-imidazole. It was labeled with ⁹⁹Tc^m in conditions of 0.1 mg SnCl₂·2H₂O at pH 6.0 and ⁹⁹Tc^mO₄^- in aqueous solution for 20 min at room temperature. The labeling yield and radiochemical purity of ⁹⁹Tc^m-PIDP are both higher than 95%. The biodistribution results show that the bone uptake is up to 8.47%ID/g which is the maximum of bone uptake at 30 min after injection of ⁹⁹Tc^m-PIDP in mice. The pharmacokinetic parameters can be estimated from the exponential equation of C=59.565e^-11.307t + 2.069e^-1.211t. The clear bone image of rabbit was obtained at 120 min after injection of ⁹⁹Tc^m-PIDP. The results indicate that ⁹⁹Tc^m-PIDP has highly selective uptake in the skeletal and low uptake, rapid clearance in soft tissues, so it would be a potential novel bone imaging agent.