99mTc-ECD brain SPECT imaging in patients with acquired immunodeficiency syndromes

^99mTc-ECD brain SPECT imaging in patients with acquired immunodeficiency syndromes

XU Hao，

WU Qiu-Lian，

LUO Jin-Xiang，

CHEN Jian

Nuclear Science and Techniques

Vol.13, No.2

pp.79-83

Published in print 01 May 2002

CLC：R817.4

25600

In order to investigate the changes of regional cerebral blood flow (rCBF) in patients with acquired immunodeficiency syndromes (AIDS), ^99mTc-ECD brain SPECT imaging was performed in 5 patients with AIDS and 16 sex and age matched normal controls, and the rCBF percentages compared to the cerebellum were calculated using a semi-quantitative processing software. Hypoperfusions in the right and left frontal, temporal, porietal lobe, basal ganglia and left thalamus were seen in 1 patient with dementia. Hypoperfusions in the right and left frontal and temporal lobe were seen in 4 asymptomatic patients. The rCBF in the right and left frontal, temporal, porietal lobe, basal ganglia and thalamus, front and pons were decreased significantly in patients with AIDS than those of the control subjects (p<0.005). It is concluded that there exists reduced cortico-subcortical rCBF in AIDS patients.

Acquired immunodeficiency syndromesBrainSingle photon emission computed tomography99mTc-ECD

References

American Academy of Neurology. Neurology, 1991, 41: 778-785

Dal Pan G J, MaArthur J H, Aylward E et al. Neurology, 1992, 42: 2125-2130

Centers for Disease Control. MMWR, 1987, 36(suppl): 1-15

Navia B A, Jordan B D, Price R W et al. Ann Neurol, 1986, 19: 517-524

Schielke E, Tasch K, Pfister W et al. Arch Neurol, 1990, 47: 1342-1345

Masdeu J C, Yudd A, Van Heertum R L et al. J Nucl Med, 1991, 32: 1471-1475

Talbot P R, Testa H J.

Nucl Med Comm, 1995, 16: 425-437

Harris G J, Pearlson G D, McArthur J C et al. AIDS, 1994, 8: 195-499

Wiley C A, Masliah E, Morey M.

Ann Neurol, 1991, 29: 651-657

Brenneman D E, Westbrook G L, Fitzgerald S P et al. Nature, 1988, 335: 639-642

Giulian D, Vaca K, Noonan C A.

Science, 1990, 250: 1593-1596