PRELIMINARY STUDY OF TRACE ELEMENTS IN HUMAN BRAIN TUMOUR TISSUES BY INAA

Zhuang Guisun，

Wang Yinsong，

Tan Mingguang，

Zhi Min，

Wang Yongji，

Pan Weiqing，

Zhang Fulin

Nuclear Science and Techniques

Vol.2, No.2

pp.100-105

Published in print 01 May 1991

21300

Elemental profiles of brain tumour tissues from 15 male patients of astrocytomas (grade I- III) and normal human brain tissues of 23 male age matched autopsies as controls have been studied by INAA. A total of 18 elements Se, Na, K, Br, Cl, Mn, Mg. S, Ca, Cu, Hg, Cr, Fe, Rb, Zn, Co, Sc and P has been determined for this purpose. The analytical results showed that compared with the normal brain tissues, concentrations of Ca, Fe, Cu, Zn, Mn, Br and Sc were significantly higher in tumour tissues and that of Rb, K and P were lower while no differences for contents of Mg, S, Cr, Na and Cl were observed. A negative correlation between P and Ca in malignant and normal brain tissues was observed.

Trace elementBrain cancerNAA

REFERENCES

[1]

Alex W.K. Chan et al., J.Neuroscience Methods, 7 (1983), 317.

[2]

H. Duflou et al., Biol. Trace Elem. Res., 13 (1987), 1.

[3]

L- O Plantin et al., ibid, 13 (1987), 69.

[4]

W.D. Ehmann et al., ibid, 13 (1987), 19.

[5]

W.D. Ehmann et al., J.Radioanal. Chem., 70 (1982), 57.

[6]

U.S.A. Tapper et al., Nucl. Instr. Meth., B22 (1987), 176.

[7]

C.C. Wei et al., Proc. of an int. symp. on in vivo body composition studies., BNL, New York, Chapter Sep.28-Oct.1, 1986, p.62.

[8]

Y.D. Cheng and G.S. Zhuang et al., J.Trace Elements in Exp. Med., 1 (1988), 19.

[9]

M. Zhi et al., Nucl. Tech. (Shanghai), 1990, in press.

[10]

Z.L. Fung et al., Modern trace element research, Chinese Environmental Science Publication, Beijing, 1987, 758.

[11]

E.J. Massaro et al., Life Sci., 14 (1975), 1934.

[12]

G.N. Schrauzer et al., J.Cancer Res., 76 (1985), 374.