The 18F-FDG uptake in non small cell lung carcinoma correlates with the DNA-grading of malignancy

The ¹⁸F-FDG uptake in non small cell lung carcinoma correlates with the DNA-grading of malignancy

WU Jin-Chang，

BAUM R P

Nuclear Science and Techniques

Vol.13, No.3

pp.187-192

Published in print 01 Aug 2002

CLC：R817.4

20100

In order to evaluate correlation of glucose metabolism and DNA ploidity of tumors, the uptake of ¹⁸F-Deoxyglucose (FDG) by PET prior to surgery and the DNA cotent and DNA-grading of malignancy (DNA-MG) of Schiff-stained nuclei obtained from fresh tumor fragments by means of image cytometry were studied, and thereafter the correlation between standardized uptake value (SUV) and (DNA-MG) was analysed in forty-nine patients with histologically proven non-small cell lung carcinoma (NSCLC). As a result of the DNA histograms of these 49 patients, 46 (93.88%) were aneuploid and only 3(6.12%) were tetraploid. A linear correlation of the SUV versus the (DNA-MG) (r=0.336, p=0.024) was found, demonstrating that ¹⁸F-FDG PET as a non-invasive metabolic imaging technique, may also provide information correlated to malignant DNA patterns which may be valuable in malignant differentiation and prognostic prediction.

Non small cell lung carcinoma18F-FDGPositron emission tomographyDNA-image cytometryDNA-grading

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