Preparation and 99mTc labeling of hydrazino nicotinamide modified RC-160 conjugate

Preparation and ^99mTc labeling of hydrazino nicotinamide modified RC-160 conjugate

HU Ji，

SUZUKI Kazuko Horiuchi，

SAJI Hideo

Nuclear Science and Techniques

Vol.12, No.2

pp.94-98

Published in print 01 May 2001

CLC：O621.3+5, O629.7, R817.9

28400

Conjugations of 6-Boc-hydrazinopyridine-3-carboxylic acid (Boc-HYNIC) with RC-160 [Lys5, Boc] using different coupling methods were studied. After deprotection, the resulted peptide conjugates were purified by RP-HPLC and characterized by Fab-MS. Combination with different coligands, ^99mTc labeling of HYNIC modified RC-160 conjugate was carried out with high radiolabeling yield (>95%). In vitro stability studies indicated that the final radio-compound remained stable at least up to 20 h when nicotinic acid (NA) used as second coligand (tricine/NA).

Conjugation99mTc labelingSomatostatin analogue

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