Labeling and stability study on 99mTc-tissue plasminogen activator as thrombus and tumor imaging agent

Labeling and stability study on ^99mTc-tissue plasminogen activator as thrombus and tumor imaging agent

Li Wei-Yi，

Cao Guo-Xian，

Yu Hui-Xin，

Zhang Rong-Jun

Nuclear Science and Techniques

Vol.07, No.01

pp.45-47

Published in print 01 Feb 1996

19300

Tissue plasminogen activator (tPA), due to its stability in acidic solution, could be conveniently labeled with ^99mTc by using stannous chloride method. More than 90% of biochemical activity was remained after the process of labeling and separation. The stability of ^99mTc-tPA was studied at different time and different pH values, respectively. The study indicates that ^99mTc-tPA would be a potential imaging agent for thrombus and tumor.

Tissue plasminogen activator99mTcImaging agentsLabelingThrombusTumors

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