Study of proton radiolysis of solid uracil film

LI Lingyun，

WANG Yugang，

XUE Jianming，

YAN Sha，

ZHAO Weijiang，

WANG Wenqing，

WU Jilan

Nuclear Science and Techniques

Vol.10, No.4

pp.221-224

Published in print 01 Nov 1999

22900

In order to understand the molecules mechanism of ion irradiation, which has been widely used in many fields such as cancer therapy, uracil, one of the bases of nucleic acid, was chosen in the low energy ion radiolysis research. The solid uracil films with mass thickness of 0.314 mg/cm² were irradiated by 200 keV H⁺ ions. The experimental results show that 200 keV H⁺ ions are effective in decomposition of uracil molecules. One of the decomposition products, 5,6-dihydro-uracil, was separated by high performance liquid chromatograph (HPLC) and detected using an UV-light detector. Its yield increases first but then decreases as the ion dose increasing. In addition, the mechanism of uracil decomposition and 5,6-dihydro-uracil formation was also discussed.

Low energy proton radiolysisUracil

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