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LABELING McAb 3H11 AND ITS Fab FRAGMENT WITH 211 At AND THEIR IMMUNOREACTIVITIES AND INJURY EFFECTS ON HUMAN GASTRIC CANCER CELLS

LABELING McAb 3H11 AND ITS Fab FRAGMENT WITH 211 At AND THEIR IMMUNOREACTIVITIES AND INJURY EFFECTS ON HUMAN GASTRIC CANCER CELLS

Liu Ning
Jin Jiannan
Zhang Shuyuan
Zhou Maolun
Wang Juan
Luo Lin
Wang Fangyuan
Luo Deyuan
Wan Wenhui
Dong Zhiwei
Nuclear Science and TechniquesVol.6, No.3pp.154-158Published in print 01 Aug 1995
22802

An antigastric cancer monoclonal antibody, 3H11, and its Fab fragment, were labeled using p-(211 At)-astatobenzoic acid (pAtBA) intermediate, in the yields of more than 30%. The results of in vitro experiments show that 211At-3H11 and 211At-3H11 Fab are stable, and have specific immunoreactivities and cytotoxic effects to human gastric cancer cell M85. The cytotoxic effects are dependent on the concentration of 211 At-3H11 or 211At-3H11 Fab and obviously stronger than that of Na211At.

211 AtGastric cancerMonoclonal antibodyFab fragmentLabeling methodImmunoreactivityCytotoxic effectIn vitro
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