CHANGES OF CATHEPSIN D AND α 2- MACROGLOBULIN IN RATS AFTER ACUTE TOTAL BODY IRRADIATION

CHANGES OF CATHEPSIN D AND α ₂- MACROGLOBULIN IN RATS AFTER ACUTE TOTAL BODY IRRADIATION

Jin Weiqiao，

Chen Shijie，

Mo Suzhen，

Fan Peifang，

Le Min，

Zhang Hao，

Li Yonghe，

He Jiewei

Nuclear Science and Techniques

Vol.1, No.3

pp.187-192

Published in print 01 Aug 1990

26200

α₂- macroglobulin (α ₂M) could stimulate the regeneration of thymic and bone marrow cells in rats received γ - irradiation, but there was very few reports concerning its mechanism. Wistar rats were irradiated by ¹⁶Co at 7 Gy, 8.5 Gy, 15 Gy total body doses. Blood plasma and some tissue's extracts were collected α ₂M level. a M activity and cathepsin D activity, malonaldehyde level were determined by radioimmunoassay, modified Schidlow's method, Barrett's method and Ohkawa's method respectively.

Alpha- 2- macroglobulinCathepsin DMalonaldehydeRadiationRat

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