A high-resolution small animal SPECT system developed at Tsinghua

RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE

A high-resolution small animal SPECT system developed at Tsinghua

DAI Tiantian，

MA Tianyu，

LIU Hui，

CUI Junjian，

WEI Qingyang，

LIU Yaqiang，

WANG Shi

Nuclear Science and Techniques

Vol.22, No.6

pp.344-348

Published in print 20 Dec 2011

DOI：10.13538/j.1001-8042/nst.22.344-348

37902

An SPECT system dedicated to small animal imaging shall be of a millimeter spatial resolution or even better. This study was aimed at achieving 0.5-mm spatial resolution for a small animal SPECT system at low cost. It was developed from a single-head clinical SPECT scanner, with a seven-pinhole collimator and a four-degree-of- freedom motion control stage. Several key techniques were developed, including high-resolution image reconstruction algorithm, high accuracy geometrical calibration method, and optimized system matrix derivation scheme. The system matrix was derived from Monte-Carlo simulation and de-noised by fitting each point spread function to a two dimensional Gaussian function. Experiments of point source and ultra micro hot rod phantom were conducted. With a spatial resolution of 0.5–0.6 mm, this system provides a practical way for low-cost high-resolution animal imaging on a clinic SPECT system.

SPECTMulti-pinhole collimatorHigh resolutionSystem matrixImage reconstruction

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