Preparation and characteristics of 117mSn-HEDTMP

Preparation and characteristics of ^117mSn-HEDTMP

HE Jia-Heng，

LUO Shun-Zhong，

YANG Yu-Qing，

PU Man-Fei，

WANG Guan-Quan，

Bing Wen-Zheng

Nuclear Science and Techniques

Vol.13, No.2

pp.105-109

Published in print 01 May 2002

CLC：O621.3+5, R817.5

27000

Tin-117m(t_1/2 14d; γ 159keV, 86%) is an ideal tracer for studying biological behavior of tin compounds as well as for developing clinically-useful radio-pharmaceuticals. It had been reported that Sn-117m[4+] DTPA has unexpectedly high bone uptake and bone-to-blood ratio, and is potentially useful as an agent for skeletal scintigraphy and radiotherapy of bone tumors. In this work, HEDTMP [N-(2-hydroxyethyl) ethlenediamine-1,1,2-tri (methylene phosphonic acid)] was synthesized. Let it form complex with ^117mSn. The formation conditions, stability and distribution coefficient between oil and water of the complex were investigated.

117mSnHEDTMPBone tumor

References

Campa J AIII. Semin Nucl Med, 1992, 22: 310

Li Q L, Zhang X D.

Nucl Tech (in Chinese), 2001, 24(1): 76-80

Sriva stava S C, Meinken G E, Richards P et al. Int J Nucl Med Biol, 1985, 12: 167

Oster Z H, Som P, Srivastava S C et al. Int J Nucl Med Biol, 1985, 12: 175

Wang L S, Han S K.

Molecule structure, character and activity. Beijing: Chemistry industry publishing company, 1997. 8