Synthesis of highly concentrated, carrier free 188Re-mercaptoacetyltriglycine

Synthesis of highly concentrated, carrier free ¹⁸⁸Re-mercaptoacetyltriglycine

ZHANG Xiu-Li，

WANG Yong-Xian，

LI Jun-Ling，

ZHANG Chun-Fu，

WANG Li-Hua，

YIN Duan-Zhi

Nuclear Science and Techniques

Vol.13, No.4

pp.237-243

Published in print 01 Nov 2002

CLC：O615.4

32600

Chelation of ¹⁸⁸Re to compounds such as MAG₃ will further reduce the radiation dose to the patient in case of balloon rupture through the rapid excretion from the body. In order to prepare highly concentrated, carrier free ¹⁸⁸Re-MAG₃, Sbenzoyl mercaptoacetyltriglycine (S-Bz-MAG₃) was synthesized, labeled with carrier free ¹⁸⁸Re, The overall yield of S-Bz-MAG₃ is higher than those published in the literature. Dependence of the labeling yield of ¹⁸⁸Re-MAG₃ upon concentrations of reducing agent, pH, reaction time, etc. was examined and optimum conditions were confirmed. The concentration procedure was succeeded with Sep-Pak C18 cartridge to obtain highly concentrated ¹⁸⁸Re-MAG₃. In the case of optimun conditions, the labeling yield of ¹⁸⁸Re-MAG₃ was more than 98%. Radiochemical purity of ¹⁸⁸Re-MAG₃ was more than 92% after 24 hour storage at room temperature.

188Re-MAG3SynthesisLabelingCarrier freeRIT

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