Catalytic protection of stannous ion by ascorbic acid in diphosphonic acids solutions

Liu Guo-Zheng，

Liu Fei，

Miao Zeng-Xing，

Wang Yi-Shan，

Fang Ji-Dong

Nuclear Science and Techniques

Vol.9, No.2

pp.121-123

Published in print 01 May 1998

20200

The protective ability of ascorbic acid (Vc) on stannous ion and the influence of light irradiation on the stability of stannous ion in diphosphonate medium at pH=5 have been examined in order to attain minimal loss of stannous ion during the production of lyophilized radiopharmaceutical kits. The sum of stannous ion and Vc was determined with iodometric method. It was shown that the protective ability of Vc was still strong at Vc concentration much lower than that of stannous ion and the illumination by fluorescent lamp was unfavorable to the stability of stannous ion. The change of pH in the range 3〜9 did not affect the action of Vc significantly.

Stability of stannous ionBone imaging kitsAscorbic acidLight irradiation

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