Synthesis and radioiodinated labeling of p-iodophenyl pentadecanoic acid

Wu Chun-Ying,，

Ji Shu-Ren,，

Fang Ping

Nuclear Science and Techniques

Vol.9, No.4

pp.246-250

Published in print 01 Nov 1998

41600

A new method for the preparation of p-iodophenyl pentadecanoic acid (IPPA) has been developed. The synthesis are described, and physical properties of IPPA are characterized by IR, ¹HNMR, elementary analysis and MS. ¹²⁵I-IPPA can be easily prepared by two methods: direct labeling and solid-phase iodo-exchange labeling, and the yields of labeling are 80% and 65%, respectively. The radiochemical purities are higher than 98% after being extracted with chloroform and hexane.

p-iodophenyl pentadecanoic acidFatty acidSynthesis125I-IPPA125I-labeling

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