The Pharmacokinetics local model for studying kinetic action of pharmaceuticals in the specific part of the body is established on the basis of the compartment model. A series of formulae is deduced, and with them the pharmacokinetic equation and several important parameters can be obtained. The local model successfully expanded the area of pharmacokinetics from the compartment model, which is mainly dealing with kinetic action of pharmaceuticals in blood, to the local model, which can study kinetic action of pharmaceuticals in any organ, tissue or fluid.