THE METABOLISM OF TITANIUM AND OTHER ELEMENTS IN WISTER RATS

Liu Nianqing，

Ji Yunjing，

Wang Min，

Zhang Xiaofeng，

Yan Lingna，

Li Jianlin，

Jin Feng，

Feng Songlin，

Zhong Ming

Nuclear Science and Techniques

Vol.2, No.3

pp.178-183

Published in print 01 Aug 1991

22900

The concentrations of Ti and Ca, P, K, Fe, Cu and Zn in blood samples were determined by PIXE after a single intravenous and a single oral dosing with titanium- ascorbate (Ti- Vc) in Wister rats. Following the intravenous injection with 50 mg Ti- Vc/kg body weight, the absorption, distribution and clearance in blood could be described by an exponential equation of three terms. After gavaged with 500 mg Ti- Vc/kg body weight, at 1.5 h the content of Ti reached the highest level. The concentration of Ca was increasing with the absorption, distribution and clearance of Ti in blood. The contents of Fe and K were decreasing. And the contents of Cu and Zn were significantly fluctuating. The effect of Ti on animal growth could be explained by the fact that Ti- Vc supplementation could promote the absorption of Ca.

PIXE Titanium- ascorbatePharmacokineticsDosingMajor and trace elements

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