¹⁸⁸Re-tin sulfur colloid (TSC) was prepared to compare its biodistribution characteristics with ¹⁸⁸Re-macroaggregates album (MAA) after transhepatic arterial embolization (TAE) in rabbits bearing VX₂ liver tumor. Labeling efficiencies of the ¹⁸⁸Re-TSC and ¹⁸⁸Re-MAA were 99.94%±0.04% and 99.95%±0.03%, respectively, and they were stable for 72 h in human serum. Sintigraphy and biodistribution in 31 rabbits bearing VX₂ liver tumor after transcatherter hepatic arterial injection of the radiopharmaceuticals were performed, and relevant activity accumulated mostly in the tumor. The percentage of the injected dose per gram of wet tissue (%ID/g) of ¹⁸⁸Re-TSC and ¹⁸⁸Re-MAA were calculated. Tumor uptake of ¹⁸⁸Re-TSC at 1 h and 24 h were 24.32%±11.93% and 21.88%±18.29%, and the radioactive ratios of tumor/liver were 70.89±19.58 and 17.42±13.96, respectively. Tumor uptake of ¹⁸⁸Re-MAA at 1 h and 24 h were 38.78%±30.23% and 15.98%±26.64%, and the radioactive ratio of tumor/liver of ¹⁸⁸Re-MAA were 39.71±25.06 and 8.13±4.61, respectively. ¹⁸⁸Re-TSC is a potential radiopharmaceutical for the therapy of tumors.