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ELECTRON MICROSCOPIC AUTORADIOGRAPHIC STUDY ON SUBCELLULAR LOCALIZATION OF FISSION PRODUCT 147Pm IN TISSUE CELLS

ELECTRON MICROSCOPIC AUTORADIOGRAPHIC STUDY ON SUBCELLULAR LOCALIZATION OF FISSION PRODUCT 147Pm IN TISSUE CELLS

Zhu Shoupeng
Wang Yuanchang
Nuclear Science and TechniquesVol.5, No.4pp.206-211Published in print 01 Nov 1994
36600

The early risk of internal contaminated accumulation of 147Pm is in blood cells and endothelial cells, especially in red blood cells. Then 147Pm is selectively deposited in ultrastructure of liver cells, such as in nucleus, nucleolus, rough endoplasmic reticulum, mitochondria and microbodies. Dense tracks also appear in mitochondria and lysosome of pedal cells within renal corpuscle, and so does in nucleus as well as in mitochondria and microbodies of epicyte of kidney near-convoluted tubule. With the prolongation of observing time, 147Pm is selectively and steadily deposited in subcellular level of organic component for bone. Substantial amount of 147Pm is taken up into the nuclear fraction of osteoclasts and osteoblasts. Particularly, in organelles 147Pm is mainly accumulated in rough endoplasmic reticulum and in mitochondria. Autoradiographic tracks especially localize in combined point between Golgi complex and transitive vesicle of rough endoplasmic reticulum. In addition, numerous 147Pm deposited in collagenous fibre within interstitial of bone cells is hardly excreted.

Electron microscopic autoradiographyAccumulationFission product147PmSubcellular level
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