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THE INHIBITION EFFECT OF 211At-Te COLLOID AND Na211 At INJECTIONS ON MURINE EHRLICH ASCITES TUMOR CELLS

THE INHIBITION EFFECT OF 211At-Te COLLOID AND Na211 At INJECTIONS ON MURINE EHRLICH ASCITES TUMOR CELLS

Wang Juan
Wang Xizhong
Zhang Jiazao
Wang Zhishu
Jin Jiannan
Zhang Shuyuan
Xu Daoquan
Chen Wenyuan
Zhou Maolun
Nuclear Science and TechniquesVol.3, No.1pp.40-44Published in print 01 Feb 1992
37300

Na211 At and 211At-Te colloid injections are prepared. It has been demonstrated that the 211At-Te colloid is stable in vivo and vitro, and can be applied in the study of biology and medicine. In the report, the model of Murine Ehrlich Ascites Cells cultured in vivo and vitro is elected for a series of experiments. It has been proved that Na211 At and 211At-Te colloid injections possess an inhibition effect on tumor cells. The inhibition effect was expressed in surviving of the mice and inhibiting growth of tumor as well as the changes of enzyme activity. Meanwhile, it was also noticed that Na211 At and 211At-Te colloid injections of various dose inhibited the absorb of pyrimidine nucleosides in Murine Ehrlich Ascites Cells. And the effect isn't reversible. It is closely related to the dose administratered and 50% inhibition rate needs about 1.48×105 Bq/ml culture.

211At211At-Te colloidAbsorbInhibition rate Prolongation rateEnzyme activity
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