Fluorescence microscopic morphology and inhibition rate studies on apoptosis of osteosarcoma cells induced by 153Sm

Fluorescence microscopic morphology and inhibition rate studies on apoptosis of osteosarcoma cells induced by ¹⁵³Sm

ZHU Shou-Peng，

XIAO Dong，

HAN Xiao-Feng

Nuclear Science and Techniques

Vol.11, No.4

pp.263-266

Published in print 01 Nov 2000

CLC：R738.1, R817.5

27400

The apoptosis of osteosarcoma cells treated with irradiation by ¹⁵³Sm-EDTMP was studied. The morphological changes in osteosarcoma cells were observed by fluorescence microscopy. It was found that osteosarcoma cells exposed with ¹⁵³Sm-EDTMP displayed significant nuclear fragmentation and marked pyknosis. With the prolongation of observing period, the membrane bound apoptotic bodies formation was observed. It should be noted, that with the lengthening of irradiation time by ¹⁵³Sm-EDTMP, the inhibition rate of proliferation of osteosarcoma cells increased progressively.

Fluorescence microscopyMorphologyInhibition rateApoptosis of osteosarcoma cells153Sm EDTMP

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