Preparation and biological evaluation of 99Tcm-labelled fatty acids

RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE

Preparation and biological evaluation of ⁹⁹Tc^m-labelled fatty acids

LIANG Jixin，

HU Ji，

CHEN Baojun，

LUO Lianzhe，

LI Hongyu，

SHEN Langtao，

LUO Zhifu

Nuclear Science and Techniques

Vol.18, No.3

pp.159-163

Published in print 20 Jun 2007

DOI：10.1016/S1001-8042(07)60039-6

CLC：R817,O623.61

37600

The aim of the present work was to develop radiolabelling fatty acids based on ⁹⁹Tc^m carbonyl chemistry for heart imaging. Undecanoic acids functionalised with iminodiacetatic acid and cysteine were radiolabelled with [⁹⁹Tc^m (CO)₃(H₂O)₃]⁺ intermediates, and their radiolabelling conditions were carefully studied. Biodistribution of ⁹⁹Tc^m (CO)₃-CYST FAC11 and ⁹⁹Tc^m (CO)₃-IDA FAC11 were observed in normal mice. The results showed that two ⁹⁹Tc^m-labelled compounds had similar profile in terms of high initial radioactivity uptake and rapid washout of radiotracers in the heart. ⁹⁹Tc^m (CO)₃-IDA FAC11 was mainly excreted via hepatobiliary system in contrast to ⁹⁹Tc^m (CO)₃-CYST FAC11, which was excreted from urinary system. It may be in part attributed to the more lipophilicity of ⁹⁹Tc^m (CO)₃-IDA FAC11 than ⁹⁹Tc^m (CO)₃-CYST FAC11.

99Tcm-labellingFatty acid derivativesBiodistribution

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