Radiolabeling of N-Succinimidyl-3-[125I]iodobenzoate intermediate

RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE

Radiolabeling of N-Succinimidyl-3-[¹²⁵I]iodobenzoate intermediate

WANG Li-Hua，

WANG Yong-Xian，

YIN Duan-Zhi，

LI Jun-Ling

Nuclear Science and Techniques

Vol.15, No.1

pp.43-45

Published in print 01 Feb 2004

CLC：TL92+3,R817.8

31200

Organostannanes were important precursors which was easy to radioiodinate. N-Succinimidyl-3- (tri-n-butylstannyl) benzoate (STB) was radiolabeled using Iodogen to get radioactive N-Succinimidyl-3-iodobenzo- ate (S¹²⁵IB) with 96% of high radiochemical yield. The optimization of labeling condition was explored in this study. S¹²⁵IB was stable at room temperature in dark. Cold SIB was prepared as a standard and IR and NMR results were given in this article.

OrganostannanesRadioiodinationStabilityIodogen

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