ADSORPTION OF 153Sm-EDTMP ON HYDROXYAPATITE

ADSORPTION OF ¹⁵³Sm-EDTMP ON HYDROXYAPATITE

Luo Shunzhong，

Qiao Jian，

Pu Manfei，

Liu Zhonglin，

Zhao Pengji，

Fu Yibei

Nuclear Science and Techniques

Vol.6, No.4

pp.241-245

Published in print 01 Nov 1995

24600

Adsorption of a promising bone tumor therapeutic agent ¹⁵³Sm-EDTMP (ethylene diamine tetramethylene phosphonic acid) and effects of several coexisting substances on adsorption and desorption were investigated using HA (hydroxyapatite) as an in vitro model. The adsorption is quantitative up to total deposition of 40 µmol/g HA, while nonquantitative when the complex concentration is above 40 µmol/g HA in the medium of pH=7.0±0.2. The uptake increases significantly with the Ca ions added. Desorption of the adsorped complexes is in the sequence of EDTMP»DTPA > EDTA. Two modes of adsorption of ¹⁵³Sm-EDTMP on HA are suggested, the first one (≤ 40µmol/g HA) quantitatively covers the available surface and the second, by which, is less efficient, additional complexes are adsorped. Non-quantitative adsorption is attributed to Coulomb repulsion while the complex concentration ranging from 40 to 80 µmol/g HA.

153Sm-EDTMPBone tumor therapeutic agentHydroxyapatiteAdsorption and desorptionAdsorption modes

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Luo Shunzhong, Qiao Jian, Pu Manfei et al. Structure measurement of ¹⁵³Sm-EDTMP (Personal communication)