KINETIC STUDY OF LIGAND EXCHANGE REACTION BETWEEN 99mTc-GH AND ECD

KINETIC STUDY OF LIGAND EXCHANGE REACTION BETWEEN ^99mTc-GH AND ECD

Fang Ping，

Wu Chunying，

Luo Shineng，

Kuang Qinfang，

Feng Yingying，

Xie Minhao，

Xi Yuefen，

Guo Yuzhi

Nuclear Science and Techniques

Vol.3, No.3

pp.183-185

Published in print 01 Aug 1992

43100

In order to explore this type of ^99mTc-GH and N₂S₂ ligands exchange reaction as a common method for the preparation of ^99mTc-N₂S₂ complexes, detailed kinetic study of ligand exchange reaction between ^99mTc-GH and ECD was carried out. This paper presents preliminary results from the study at different ligand concentrations and pH values. The ligand exchange reaction is a second order reaction. Its rate constant being pH dependent were determined as: k_pH2=1.11×10⁴ l • mol^-1 • min^-1, k_pH5=1.34×10⁴ l • mol^-1 • min^-1, k_pH6=2.24×10⁴ l • mol^-1 • min^-1.

99mTc-Glucoheptonate99mTc-ECDLigand exchange kinetics

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