SYNTHESIS OF (2-3H) BROMOACETAMIDE

SYNTHESIS OF (2-³H) BROMOACETAMIDE

Wang Guoping，

Zhou Meiying，

Zhao Xialing

Nuclear Science and Techniques

Vol.2, No.4

pp.240-241

Published in print 01 Nov 1991

23000

(2- ³H) bromoacetamide, a radiotracer of oncomelanicide for various biological studies, has been synthesized by multiple organic reactions from ³H- sodium acetate. The radiochemical purity checked by radio- HPLC was 95% and the specific activity was 11.3GBq/mmol (305mCi/mmol). Moreover, ³H- NMR spectrum indicated that all tritium atoms were labelled on the position 2.

BromoacetamideTritium labelled

REFERENCES

[1]

Arthur Murray, III and D. Lloyd Williams, Organic synthesis with isotopes, Interscience Publisher, Inc., New York, 1958, p.412.

[2]

ibid, 1958, p.328.

[3]

Zhao Xialing and Liu Jingzhi, Atomic Energy Science and Technology (in Chinese), 17 (1983), 734.