Electron microscopic observations and DNA chain fragmentation studies on apoptosis in bone tumor cells induced by 153Sm-EDTMP

Electron microscopic observations and DNA chain fragmentation studies on apoptosis in bone tumor cells induced by ¹⁵³Sm-EDTMP

Zhu Shou-Peng，

Xiao Dong，

Han Xiao-Feng

Nuclear Science and Techniques

Vol.8, No.3

pp.163-165

Published in print 01 Aug 1997

36400

The morphological changes observed by electron microscopy indicate that after internal irradiation with ¹⁵³Sm-EDTMP bone tumor cells displayed feature of apoptosis, such as margination of condensed chromatin, chromatin fragmentation, as well as the membrane-bounded apoptotic bodies formation. The quantification analysis of fragmentation DNA for bone tumor cells induced by ¹⁵³Sm-EDTMP shows that the DNA fragmentation is enhanced with the prolongation of internally irradiated time. These characteristics suggest that ¹⁵³Sm-EDTMP internal irradiation could induce bone tumor cells to go to apoptosis.

Electron microscopyDNA chain fragmentationApoptosisBone tumor cells153Sm-EDTMPWistar strain rats

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